Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D2 receptor. However, support for this hypothesis is limited to a relatively small number of observations made across several decades and und...

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Bibliographic Details
Main Authors:	Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert, Charlton, Steven J.
Format:	Article
Published:	Nature Publishing Group 2017
Subjects:	Neurotransmitters; Receptor pharmacology
Online Access:	https://eprints.nottingham.ac.uk/50603/

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