Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925

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Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925

The human P2Y2 receptor (hP2Y2R) is a G protein-coupled receptor that shows promise as a therapeutic target for many important conditions including anti-metastatic cancer therapy and more recently for the treatment of idiopathic pulmonary fibrosis. As such, there is a need for new hP2Y2R antagonists...

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Bibliographic Details
Main Authors:	Conroy, Sean, Kindon, Nicholas, Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard James, Hill, Stephen J., Kellam, Barrie, Stocks, Michael J.
Format:	Article
Published:	American Chemical Society 2018
Subjects:	P2Y2R antagonists fluorescence BRET G Protein-Coupled Receptor GPCR
Online Access:	https://eprints.nottingham.ac.uk/50574/

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