Exploiting the kinetic interplay between GPIb -VWF binding interfaces to regulate hemostasis and thrombosis

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Exploiting the kinetic interplay between GPIb -VWF binding interfaces to regulate hemostasis and thrombosis

Platelet–von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the platelet receptor glycoprotein Ibα and the A1 domain...

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Bibliographic Details
Main Authors:	Chen, Jianchung, Zhou, Hairu, Diacovo, Alexander, Zheng, X. Long, Emsley, Jonas, Diacovo, Thomas G.
Format:	Article
Published:	American Society of Hematology 2014
Online Access:	https://eprints.nottingham.ac.uk/50479/

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