Loss of epithelial Gq and G11 signaling inhibits TGFbeta production but promotes IL-33-mediated macrophage polarization and emphysema

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Loss of epithelial Gq and G11 signaling inhibits TGFbeta production but promotes IL-33-mediated macrophage polarization and emphysema

Heterotrimeric guanine nucleotide-binding protein (G protein) signaling links hundreds of G protein-coupled receptors with four G protein signaling pathways. Two of these, one mediated by Gq and G11 (Gq/11) and the other by G12 and G13 (G12/13), are implicated in the force-dependent activation of tr...

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Bibliographic Details
Main Authors:	John, A.E., Wilson, M.R., Habgood, A., Porte, J., Tatler, A.L., Stavrou, A, Miele, G, Jolly, L, Knox, A.J., Takata, M, Offermanns, S, Jenkins, R.G.
Format:	Article
Published:	American Association for the Advancement of Science 2016
Online Access:	https://eprints.nottingham.ac.uk/50300/

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