Design, synthesis, and optimisation of highly selective macrocyclic CDK9 inhibitors

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Design, synthesis, and optimisation of highly selective macrocyclic CDK9 inhibitors

Cyclin dependent kinases (CDKs) belong to a family of serine/threonine protein kinases that play a key role in cell cycle and transcriptional regulation. CDK9, in complex with its regulatory partner cyclin T1, is involved in RNA transcriptional regulation through phosphorylating the RNA polymerase I...

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Bibliographic Details
Main Author:	Gao, Rui
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2018
Online Access:	https://eprints.nottingham.ac.uk/50294/

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