Loss of the nuclear pool of ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1-cathepsin pro-oncogenic program

Loss of the nuclear pool of ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1-cathepsin pro-oncogenic program

CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer. Using an extensive and well-annotated breast cancer tissue collection, we identified the loss of nuclear but not cytoplasmic CHIP to predict more...

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Bibliographic Details
Main Authors: Luan, Haitao, Mohapatra, Bhopal C., Bielecki, Timothy A., Mushtaq, Insha, Mirza, Sameer, Jennings, Tameka A., Clubb, Robert J., An, Wei, Ahmed, Dena, El Ansari, Rokaya, Storck, Matthew D., Mishra, Nitish K., Guda, Chittibabu, Sheinin, Yuri, Meza, Jane L., Raja, Srikumar M., Rakha, Emad, Band, Vimla, Band, Hamid
Format: Article
Language:English
Published: American Association for Cancer Research 2018
Subjects:
CHIP/STUB1
ubiquitin ligase
breast cancer
ErbB2
matrix degradation
Online Access:https://eprints.nottingham.ac.uk/50047/

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