Ventromedial prefrontal volume in adolescence predicts hyperactive/inattentive symptoms in adulthood
Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated w...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2018
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| Online Access: | https://eprints.nottingham.ac.uk/50041/ |
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| author | Albaugh, Matthew Ivanova, Masha Chaarani, Bader Orr, Catherine Allgaier, Nicholas Althoff, Robert D'Alberto, Nicholas Hudson, Kelse Mackey, Scott Spechler, Philip Banaschewski, Tobias Bokde, Arun Bromberg, Uli Cattrell, Anna J.Conrod, Patricia Gowland, Penny |
| author_facet | Albaugh, Matthew Ivanova, Masha Chaarani, Bader Orr, Catherine Allgaier, Nicholas Althoff, Robert D'Alberto, Nicholas Hudson, Kelse Mackey, Scott Spechler, Philip Banaschewski, Tobias Bokde, Arun Bromberg, Uli Cattrell, Anna J.Conrod, Patricia Gowland, Penny |
| author_sort | Albaugh, Matthew |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1,104 participants (M = 14.52 yrs, SD = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -.274, p < .001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms. |
| first_indexed | 2025-11-14T20:14:59Z |
| format | Article |
| id | nottingham-50041 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:14:59Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-500412019-05-16T14:07:10Z https://eprints.nottingham.ac.uk/50041/ Ventromedial prefrontal volume in adolescence predicts hyperactive/inattentive symptoms in adulthood Albaugh, Matthew Ivanova, Masha Chaarani, Bader Orr, Catherine Allgaier, Nicholas Althoff, Robert D'Alberto, Nicholas Hudson, Kelse Mackey, Scott Spechler, Philip Banaschewski, Tobias Bokde, Arun Bromberg, Uli Cattrell, Anna J.Conrod, Patricia Gowland, Penny Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1,104 participants (M = 14.52 yrs, SD = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -.274, p < .001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms. Oxford University Press 2018-04-18 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/50041/1/CerebralCortex2018.pdf Albaugh, Matthew, Ivanova, Masha, Chaarani, Bader, Orr, Catherine, Allgaier, Nicholas, Althoff, Robert, D'Alberto, Nicholas, Hudson, Kelse, Mackey, Scott, Spechler, Philip, Banaschewski, Tobias, Bokde, Arun, Bromberg, Uli, Cattrell, Anna, J.Conrod, Patricia and Gowland, Penny (2018) Ventromedial prefrontal volume in adolescence predicts hyperactive/inattentive symptoms in adulthood. Cerebral Cortex, 29 (5). pp. 1866-1874. ISSN 1460-2199 attention-deficit/hyperactivity disorder neuroimaging ventromedial prefrontal cortex https://academic.oup.com/cercor/article/29/5/1866/4975485 doi:10.1093/cercor/bhy066 doi:10.1093/cercor/bhy066 |
| spellingShingle | attention-deficit/hyperactivity disorder neuroimaging ventromedial prefrontal cortex Albaugh, Matthew Ivanova, Masha Chaarani, Bader Orr, Catherine Allgaier, Nicholas Althoff, Robert D'Alberto, Nicholas Hudson, Kelse Mackey, Scott Spechler, Philip Banaschewski, Tobias Bokde, Arun Bromberg, Uli Cattrell, Anna J.Conrod, Patricia Gowland, Penny Ventromedial prefrontal volume in adolescence predicts hyperactive/inattentive symptoms in adulthood |
| title | Ventromedial prefrontal volume in adolescence predicts
hyperactive/inattentive symptoms in adulthood |
| title_full | Ventromedial prefrontal volume in adolescence predicts
hyperactive/inattentive symptoms in adulthood |
| title_fullStr | Ventromedial prefrontal volume in adolescence predicts
hyperactive/inattentive symptoms in adulthood |
| title_full_unstemmed | Ventromedial prefrontal volume in adolescence predicts
hyperactive/inattentive symptoms in adulthood |
| title_short | Ventromedial prefrontal volume in adolescence predicts
hyperactive/inattentive symptoms in adulthood |
| title_sort | ventromedial prefrontal volume in adolescence predicts
hyperactive/inattentive symptoms in adulthood |
| topic | attention-deficit/hyperactivity disorder neuroimaging ventromedial prefrontal cortex |
| url | https://eprints.nottingham.ac.uk/50041/ https://eprints.nottingham.ac.uk/50041/ https://eprints.nottingham.ac.uk/50041/ |