Pulmonary basaloid squamous cell carcinoma in a dog
A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, the left kidney and the cerebellum. Microscopically, the tumour consisted...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | https://eprints.nottingham.ac.uk/49991/ |
| _version_ | 1848798124702695424 |
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| author | Morey-Matamalas, Antonia de Stefani, Alberta Corbetta, Davide Grau-Roma, Llorenc de Brot, Simone |
| author_facet | Morey-Matamalas, Antonia de Stefani, Alberta Corbetta, Davide Grau-Roma, Llorenc de Brot, Simone |
| author_sort | Morey-Matamalas, Antonia |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, the left kidney and the cerebellum. Microscopically, the tumour consisted of an infiltrative, densely cellular, basaloid epithelial neoplastic growth with extensive areas of abrupt keratinization. Immunohistochemically, neoplastic cells expressed p63 and partially expressed cytokeratins 5/6. Based on these findings, the tumour was diagnosed as a primary pulmonary basaloid squamous cell carcinoma (BSSC) with metastasis to regional lymph nodes, kidney and brain. As far as the authors are aware, this is the first description of BSCC in an animal species. |
| first_indexed | 2025-11-14T20:14:47Z |
| format | Article |
| id | nottingham-49991 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:14:47Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-499912020-05-04T19:30:40Z https://eprints.nottingham.ac.uk/49991/ Pulmonary basaloid squamous cell carcinoma in a dog Morey-Matamalas, Antonia de Stefani, Alberta Corbetta, Davide Grau-Roma, Llorenc de Brot, Simone A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, the left kidney and the cerebellum. Microscopically, the tumour consisted of an infiltrative, densely cellular, basaloid epithelial neoplastic growth with extensive areas of abrupt keratinization. Immunohistochemically, neoplastic cells expressed p63 and partially expressed cytokeratins 5/6. Based on these findings, the tumour was diagnosed as a primary pulmonary basaloid squamous cell carcinoma (BSSC) with metastasis to regional lymph nodes, kidney and brain. As far as the authors are aware, this is the first description of BSCC in an animal species. Elsevier 2018-02-03 Article PeerReviewed Morey-Matamalas, Antonia, de Stefani, Alberta, Corbetta, Davide, Grau-Roma, Llorenc and de Brot, Simone (2018) Pulmonary basaloid squamous cell carcinoma in a dog. Journal of Comparative Pathology, 159 . pp. 11-15. ISSN 1532-3129 https://www.sciencedirect.com/science/article/pii/S0021997517305327 doi:10.1016/j.jcpa.2017.12.007 doi:10.1016/j.jcpa.2017.12.007 |
| spellingShingle | Morey-Matamalas, Antonia de Stefani, Alberta Corbetta, Davide Grau-Roma, Llorenc de Brot, Simone Pulmonary basaloid squamous cell carcinoma in a dog |
| title | Pulmonary basaloid squamous cell carcinoma in a dog |
| title_full | Pulmonary basaloid squamous cell carcinoma in a dog |
| title_fullStr | Pulmonary basaloid squamous cell carcinoma in a dog |
| title_full_unstemmed | Pulmonary basaloid squamous cell carcinoma in a dog |
| title_short | Pulmonary basaloid squamous cell carcinoma in a dog |
| title_sort | pulmonary basaloid squamous cell carcinoma in a dog |
| url | https://eprints.nottingham.ac.uk/49991/ https://eprints.nottingham.ac.uk/49991/ https://eprints.nottingham.ac.uk/49991/ |