SNi from SN2: a front-face mechanism ‘synthase’ engineered from a retaining hydrolase

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SNi from SN2: a front-face mechanism ‘synthase’ engineered from a retaining hydrolase

SNi or SNi-like mechanisms, in which leaving group departure and nucleophile approach occur on the same ‘front’ face, have been observed previously experimentally and computationally in both the chemical and enzymatic (glycosyltransferase) substitution reactions of α-glycosyl electrophiles. Given th...

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Bibliographic Details
Main Authors:	Iglesias-Fernández, Javier, Hancock, Susan M., Lee, Seung Seo, Khan, Moala, Kirkpatrick, Jo, Oldham, Neil J., McAuley, Katherine, Fordham-Skelton, Anthony, Rovira, Carme, Davis, Benjamin G.
Format:	Article
Published:	Nature Publishing Group 2017
Online Access:	https://eprints.nottingham.ac.uk/49892/

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