Screening for hepatocellular carcinoma: patient selection and perspectives
Hepatocellular carcinoma (HCC) develops on the background of liver cirrhosis often from multiple, simultaneous factors. The diagnosis of a single small HCC comes with good prognosis and provides a potential for cure. In contrast, the diagnosis of multifocal, large HCC has high mortality and poor pro...
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| Format: | Article |
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Dove Medical Press
2017
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| Online Access: | https://eprints.nottingham.ac.uk/49864/ |
| _version_ | 1848798096930111488 |
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| author | Fateen, Waleed Ryder, Stephen |
| author_facet | Fateen, Waleed Ryder, Stephen |
| author_sort | Fateen, Waleed |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Hepatocellular carcinoma (HCC) develops on the background of liver cirrhosis often from multiple, simultaneous factors. The diagnosis of a single small HCC comes with good prognosis and provides a potential for cure. In contrast, the diagnosis of multifocal, large HCC has high mortality and poor prognosis. Unfortunately, the majority of HCC is diagnosed at such late stages. A surveillance program endorsed by regional liver societies involves six-monthly ultrasound surveillance of at-risk patients. This had been in action for the last two decades. It has led to marked increase in the proportion of patients presenting with small unifocal nodules found on surveillance. The development of tools to enhance our ability in optimizing available surveillance is likely to improve the prognosis of patients with HCC. In this review, we discuss the difficulties in utilizing HCC surveillance and possible means of improvement. |
| first_indexed | 2025-11-14T20:14:21Z |
| format | Article |
| id | nottingham-49864 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:14:21Z |
| publishDate | 2017 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-498642020-05-04T18:46:07Z https://eprints.nottingham.ac.uk/49864/ Screening for hepatocellular carcinoma: patient selection and perspectives Fateen, Waleed Ryder, Stephen Hepatocellular carcinoma (HCC) develops on the background of liver cirrhosis often from multiple, simultaneous factors. The diagnosis of a single small HCC comes with good prognosis and provides a potential for cure. In contrast, the diagnosis of multifocal, large HCC has high mortality and poor prognosis. Unfortunately, the majority of HCC is diagnosed at such late stages. A surveillance program endorsed by regional liver societies involves six-monthly ultrasound surveillance of at-risk patients. This had been in action for the last two decades. It has led to marked increase in the proportion of patients presenting with small unifocal nodules found on surveillance. The development of tools to enhance our ability in optimizing available surveillance is likely to improve the prognosis of patients with HCC. In this review, we discuss the difficulties in utilizing HCC surveillance and possible means of improvement. Dove Medical Press 2017-05-17 Article PeerReviewed Fateen, Waleed and Ryder, Stephen (2017) Screening for hepatocellular carcinoma: patient selection and perspectives. Journal of Hepatocellular Carcinoma, 2017 (4). pp. 71-79. ISSN 2253-5969 hepatocellular carcinoma surveillance screening risk stratification https://doi.org/10.2147/JHC.S105777 doi:10.2147/JHC.S105777 doi:10.2147/JHC.S105777 |
| spellingShingle | hepatocellular carcinoma surveillance screening risk stratification Fateen, Waleed Ryder, Stephen Screening for hepatocellular carcinoma: patient selection and perspectives |
| title | Screening for hepatocellular carcinoma: patient selection and perspectives |
| title_full | Screening for hepatocellular carcinoma: patient selection and perspectives |
| title_fullStr | Screening for hepatocellular carcinoma: patient selection and perspectives |
| title_full_unstemmed | Screening for hepatocellular carcinoma: patient selection and perspectives |
| title_short | Screening for hepatocellular carcinoma: patient selection and perspectives |
| title_sort | screening for hepatocellular carcinoma: patient selection and perspectives |
| topic | hepatocellular carcinoma surveillance screening risk stratification |
| url | https://eprints.nottingham.ac.uk/49864/ https://eprints.nottingham.ac.uk/49864/ https://eprints.nottingham.ac.uk/49864/ |