SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors

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SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors

Purpose: We have previously shown that supraoptimal signaling of high avidity T cells leads to high expression of PD-1 and inhibition of proliferation. This study was designed to see if this effect could be mitigated by combining a vaccine that stimulates high avidity T cells with PD-1 blockade....

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Bibliographic Details
Main Authors:	Xue, Wei, Brentville, Victoria A., Symonds, Peter, Cook, Katherine, Yagita, Hideo, Metheringham, Rachael L., Durrant, Lindy
Format:	Article
Published:	Impact Journals 2016
Subjects:	DNA vaccine; Fc targeting; PD-1 blockade; melanoma; tumor rejection
Online Access:	https://eprints.nottingham.ac.uk/49786/

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