SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors
Purpose: We have previously shown that supraoptimal signaling of high avidity T cells leads to high expression of PD-1 and inhibition of proliferation. This study was designed to see if this effect could be mitigated by combining a vaccine that stimulates high avidity T cells with PD-1 blockade....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Impact Journals
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/49786/ |