Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy

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Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy

Several histone deacetylase inhibitors including Vorinostat have received FDA approval for the treatment of haematological malignancies. However, data from these trials indicate that Vorinostat has limited efficacy as a monotherapy, prompting the need for rational design of combination therapies. A...

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Bibliographic Details
Main Authors:	Hay, Jodie F., Lappin, Katrina, Liberante, Fabio, Kettyle, Laura M., Matchett, Kyle B., Thompson, Alexander, Mills, Ken I.
Format:	Article
Published:	Impact Journals 2017
Subjects:	acute myeloid leukaemia Vorinostat HDAC epigenetics
Online Access:	https://eprints.nottingham.ac.uk/49754/

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