Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy

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Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy

Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of less than 8%. In an attempt to improve this, epigenetic modifying agents have been combined as therapies in clinical studies. In particular combinations with Decitabine and V...

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Bibliographic Details
Main Authors:	Young, Christine S., Clarke, Kathryn M., Kettyle, Laura M., Thompson, Alexander, Mills, Ken I.
Format:	Article
Published:	Impact Journals 2017
Subjects:	epigenetic combination therapies AXL receptor tyrosine kinase acute myeloid leukemia HDAC inhibitors DNMT inhibitors
Online Access:	https://eprints.nottingham.ac.uk/49749/

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