Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells

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Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells

The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of solid tumors. However, despite HOX proteins playin...

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Bibliographic Details
Main Authors:	Alharbi, Raed A., Pandha, Hardev S., Simpson, Guy R., Pettengell, Ruth, Poterlowicz, Krzysztof, Thompson, Alexander, Harrington, Kevin, El-Tanani, Mohamed, Morgan, Richard
Format:	Article
Published:	Impact Journals 2017
Subjects:	acute myeloid leukemia HOX HXR9 necroptosis protein kinase C
Online Access:	https://eprints.nottingham.ac.uk/49748/

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