Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery

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Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery

Pulmonary delivery of protein therapeutics has considerable clinical potential for treating both local and systemic diseases. However, poor protein conformational stability, immunogenicity and protein degradation by proteolytic enzymes in the lung are major challenges to overcome for the development...

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Bibliographic Details
Main Authors:	Nieto-Orellana, Alejandro, Coghlan, David, Rothery, Malcolm, Falcone, Franco H., Bosquillon, Cynthia, Childerhouse, Nick, Mantovani, Giuseppe, Stolnik, Snow
Format:	Article
Published:	Elsevier 2018
Subjects:	dry powder pulmonary delivery polymer-protein complexes spray-drying protein delivery non-covalent complexes
Online Access:	https://eprints.nottingham.ac.uk/49682/

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