Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge
Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing...
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| Format: | Article |
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Elsevier
2012
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| Online Access: | https://eprints.nottingham.ac.uk/49641/ |
| _version_ | 1848798044384919552 |
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| author | Feldwisch-Drentrup, Hinnerk Barrett, Adam B. Smith, Michael T. van Rossum, Mark C.W. |
| author_facet | Feldwisch-Drentrup, Hinnerk Barrett, Adam B. Smith, Michael T. van Rossum, Mark C.W. |
| author_sort | Feldwisch-Drentrup, Hinnerk |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes. |
| first_indexed | 2025-11-14T20:13:31Z |
| format | Article |
| id | nottingham-49641 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:13:31Z |
| publishDate | 2012 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-496412020-05-04T16:34:04Z https://eprints.nottingham.ac.uk/49641/ Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge Feldwisch-Drentrup, Hinnerk Barrett, Adam B. Smith, Michael T. van Rossum, Mark C.W. Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes. Elsevier 2012-09-15 Article PeerReviewed Feldwisch-Drentrup, Hinnerk, Barrett, Adam B., Smith, Michael T. and van Rossum, Mark C.W. (2012) Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge. Journal of Neuroscience Methods, 210 (1). pp. 15-21. ISSN 1872-678X Synaptic transmission ; Noise analysis ; Stochastic channels ; Neural variability https://www.sciencedirect.com/science/article/pii/S0165027011006601?via%3Dihub doi:10.1016/j.jneumeth.2011.11.004 doi:10.1016/j.jneumeth.2011.11.004 |
| spellingShingle | Synaptic transmission ; Noise analysis ; Stochastic channels ; Neural variability Feldwisch-Drentrup, Hinnerk Barrett, Adam B. Smith, Michael T. van Rossum, Mark C.W. Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge |
| title | Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge |
| title_full | Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge |
| title_fullStr | Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge |
| title_full_unstemmed | Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge |
| title_short | Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge |
| title_sort | fluctuations in the open time of synaptic channels: an application to noise analysis based on charge |
| topic | Synaptic transmission ; Noise analysis ; Stochastic channels ; Neural variability |
| url | https://eprints.nottingham.ac.uk/49641/ https://eprints.nottingham.ac.uk/49641/ https://eprints.nottingham.ac.uk/49641/ |