Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise
Electrical signaling in neurons is mediated by the opening and closing of large numbers of individual ion channels. The ion channels' state transitions are stochastic and introduce fluctuations in the macroscopic current through ion channel populations. This creates an unavoidable source of int...
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| Format: | Article |
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Frontiers
2014
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| Online Access: | https://eprints.nottingham.ac.uk/49636/ |
| _version_ | 1848798043010236416 |
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| author | O'Donnell, Cian van Rossum, Mark C.W. |
| author_facet | O'Donnell, Cian van Rossum, Mark C.W. |
| author_sort | O'Donnell, Cian |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Electrical signaling in neurons is mediated by the opening and closing of large numbers of individual ion channels. The ion channels' state transitions are stochastic and introduce fluctuations in the macroscopic current through ion channel populations. This creates an unavoidable source of intrinsic electrical noise for the neuron, leading to fluctuations in the membrane potential and spontaneous spikes. While this effect is well known, the impact of channel noise on single neuron dynamics remains poorly understood. Most results are based on numerical simulations. There is no agreement, even in theoretical studies, on which ion channel type is the dominant noise source, nor how inclusion of additional ion channel types affects voltage noise. Here we describe a framework to calculate voltage noise directly from an arbitrary set of ion channel models, and discuss how this can be use to estimate spontaneous spike rates. |
| first_indexed | 2025-11-14T20:13:29Z |
| format | Article |
| id | nottingham-49636 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:13:29Z |
| publishDate | 2014 |
| publisher | Frontiers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-496362020-05-04T16:54:37Z https://eprints.nottingham.ac.uk/49636/ Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise O'Donnell, Cian van Rossum, Mark C.W. Electrical signaling in neurons is mediated by the opening and closing of large numbers of individual ion channels. The ion channels' state transitions are stochastic and introduce fluctuations in the macroscopic current through ion channel populations. This creates an unavoidable source of intrinsic electrical noise for the neuron, leading to fluctuations in the membrane potential and spontaneous spikes. While this effect is well known, the impact of channel noise on single neuron dynamics remains poorly understood. Most results are based on numerical simulations. There is no agreement, even in theoretical studies, on which ion channel type is the dominant noise source, nor how inclusion of additional ion channel types affects voltage noise. Here we describe a framework to calculate voltage noise directly from an arbitrary set of ion channel models, and discuss how this can be use to estimate spontaneous spike rates. Frontiers 2014-09-04 Article PeerReviewed O'Donnell, Cian and van Rossum, Mark C.W. (2014) Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise. Frontiers in Computational Neuroscience, 8 . p. 105. ISSN 1662-5188 channel noise voltage-gated ion channels Hodgkin–Huxley spontaneous firing simulation https://www.frontiersin.org/articles/10.3389/fncom.2014.00105/full doi:10.3389/fncom.2014.00105 doi:10.3389/fncom.2014.00105 |
| spellingShingle | channel noise voltage-gated ion channels Hodgkin–Huxley spontaneous firing simulation O'Donnell, Cian van Rossum, Mark C.W. Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise |
| title | Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise |
| title_full | Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise |
| title_fullStr | Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise |
| title_full_unstemmed | Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise |
| title_short | Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise |
| title_sort | systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise |
| topic | channel noise voltage-gated ion channels Hodgkin–Huxley spontaneous firing simulation |
| url | https://eprints.nottingham.ac.uk/49636/ https://eprints.nottingham.ac.uk/49636/ https://eprints.nottingham.ac.uk/49636/ |