Spontaneous action potentials and neural coding in unmyelinated axons
The voltage-gated Na and K channels in neurons are responsible for action potential generation. Because ion channels open and close in a stochastic fashion, spontaneous (ectopic) action potentials can result even in the absence of stimulation. While spontaneous action potentials have been studied in...
| Main Authors: | , |
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| Format: | Article |
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MIT Press
2015
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| Online Access: | https://eprints.nottingham.ac.uk/49635/ |
| _version_ | 1848798042754383872 |
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| author | O'Donnell, Cian van Rossum, Mark C.W. |
| author_facet | O'Donnell, Cian van Rossum, Mark C.W. |
| author_sort | O'Donnell, Cian |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The voltage-gated Na and K channels in neurons are responsible for action potential generation. Because ion channels open and close in a stochastic fashion, spontaneous (ectopic) action potentials can result even in the absence of stimulation. While spontaneous action potentials have been studied in detail in single-compartment models, studies on spatially extended processes have been limited. The simulations and analysis presented here show that spontaneous rate in unmyelinated axon depends nonmonotonically on the length of the axon, that the spontaneous activity has sub-Poisson statistics, and that neural coding can be hampered by the spontaneous spikes by reducing the probability of transmitting the first spike in a train. |
| first_indexed | 2025-11-14T20:13:29Z |
| format | Article |
| id | nottingham-49635 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:13:29Z |
| publishDate | 2015 |
| publisher | MIT Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-496352020-05-04T17:05:47Z https://eprints.nottingham.ac.uk/49635/ Spontaneous action potentials and neural coding in unmyelinated axons O'Donnell, Cian van Rossum, Mark C.W. The voltage-gated Na and K channels in neurons are responsible for action potential generation. Because ion channels open and close in a stochastic fashion, spontaneous (ectopic) action potentials can result even in the absence of stimulation. While spontaneous action potentials have been studied in detail in single-compartment models, studies on spatially extended processes have been limited. The simulations and analysis presented here show that spontaneous rate in unmyelinated axon depends nonmonotonically on the length of the axon, that the spontaneous activity has sub-Poisson statistics, and that neural coding can be hampered by the spontaneous spikes by reducing the probability of transmitting the first spike in a train. MIT Press 2015-04-30 Article PeerReviewed O'Donnell, Cian and van Rossum, Mark C.W. (2015) Spontaneous action potentials and neural coding in unmyelinated axons. Neural Computation, 27 (4). pp. 801-818. ISSN 1530-888X https://www.mitpressjournals.org/doi/10.1162/NECO_a_00705 doi:10.1162/NECO_a_00705 doi:10.1162/NECO_a_00705 |
| spellingShingle | O'Donnell, Cian van Rossum, Mark C.W. Spontaneous action potentials and neural coding in unmyelinated axons |
| title | Spontaneous action potentials and neural coding in unmyelinated axons |
| title_full | Spontaneous action potentials and neural coding in unmyelinated axons |
| title_fullStr | Spontaneous action potentials and neural coding in unmyelinated axons |
| title_full_unstemmed | Spontaneous action potentials and neural coding in unmyelinated axons |
| title_short | Spontaneous action potentials and neural coding in unmyelinated axons |
| title_sort | spontaneous action potentials and neural coding in unmyelinated axons |
| url | https://eprints.nottingham.ac.uk/49635/ https://eprints.nottingham.ac.uk/49635/ https://eprints.nottingham.ac.uk/49635/ |