Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning
Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields wit...
| Main Authors: | , , , |
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| Format: | Article |
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eLife Sciences Publications
2015
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| Online Access: | https://eprints.nottingham.ac.uk/49628/ |
| _version_ | 1848798041194102784 |
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| author | Costa, Rui Ponte Froemke, Robert C. Sjöström, P. Jesper van Rossum, Mark C.W. |
| author_facet | Costa, Rui Ponte Froemke, Robert C. Sjöström, P. Jesper van Rossum, Mark C.W. |
| author_sort | Costa, Rui Ponte |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. Moreover, learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes. |
| first_indexed | 2025-11-14T20:13:28Z |
| format | Article |
| id | nottingham-49628 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:13:28Z |
| publishDate | 2015 |
| publisher | eLife Sciences Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-496282020-05-04T17:14:37Z https://eprints.nottingham.ac.uk/49628/ Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning Costa, Rui Ponte Froemke, Robert C. Sjöström, P. Jesper van Rossum, Mark C.W. Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. Moreover, learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes. eLife Sciences Publications 2015-08-26 Article PeerReviewed Costa, Rui Ponte, Froemke, Robert C., Sjöström, P. Jesper and van Rossum, Mark C.W. (2015) Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife, 4 . e09457. ISSN 2050-084X https://elifesciences.org/articles/09457 doi:10.7554/eLife.09457 doi:10.7554/eLife.09457 |
| spellingShingle | Costa, Rui Ponte Froemke, Robert C. Sjöström, P. Jesper van Rossum, Mark C.W. Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning |
| title | Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning |
| title_full | Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning |
| title_fullStr | Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning |
| title_full_unstemmed | Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning |
| title_short | Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning |
| title_sort | unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning |
| url | https://eprints.nottingham.ac.uk/49628/ https://eprints.nottingham.ac.uk/49628/ https://eprints.nottingham.ac.uk/49628/ |