Functional consequences of pre- and postsynaptic expression of synaptic plasticity
Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of...
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| Format: | Article |
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Royal Society, The
2017
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| Online Access: | https://eprints.nottingham.ac.uk/49625/ |
| _version_ | 1848798040885821440 |
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| author | Costa, Rui Ponte Mizusaki, Beatriz E.P. Sjöström, P. Jesper van Rossum, Mark C.W. |
| author_facet | Costa, Rui Ponte Mizusaki, Beatriz E.P. Sjöström, P. Jesper van Rossum, Mark C.W. |
| author_sort | Costa, Rui Ponte |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'. |
| first_indexed | 2025-11-14T20:13:27Z |
| format | Article |
| id | nottingham-49625 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:13:27Z |
| publishDate | 2017 |
| publisher | Royal Society, The |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-496252020-05-04T18:32:01Z https://eprints.nottingham.ac.uk/49625/ Functional consequences of pre- and postsynaptic expression of synaptic plasticity Costa, Rui Ponte Mizusaki, Beatriz E.P. Sjöström, P. Jesper van Rossum, Mark C.W. Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'. Royal Society, The 2017-01-02 Article PeerReviewed Costa, Rui Ponte, Mizusaki, Beatriz E.P., Sjöström, P. Jesper and van Rossum, Mark C.W. (2017) Functional consequences of pre- and postsynaptic expression of synaptic plasticity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372 (1715). pp. 1-10. ISSN 1471-2970 synaptic plasticity Hebbian plasticity spike-timing-dependent plasticity homoeostatic plasticity long-term potentiation synaptic release http://rstb.royalsocietypublishing.org/content/372/1715/20160153 doi:10.1098/rstb.2016.0153 doi:10.1098/rstb.2016.0153 |
| spellingShingle | synaptic plasticity Hebbian plasticity spike-timing-dependent plasticity homoeostatic plasticity long-term potentiation synaptic release Costa, Rui Ponte Mizusaki, Beatriz E.P. Sjöström, P. Jesper van Rossum, Mark C.W. Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_full | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_fullStr | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_full_unstemmed | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_short | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_sort | functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| topic | synaptic plasticity Hebbian plasticity spike-timing-dependent plasticity homoeostatic plasticity long-term potentiation synaptic release |
| url | https://eprints.nottingham.ac.uk/49625/ https://eprints.nottingham.ac.uk/49625/ https://eprints.nottingham.ac.uk/49625/ |