MDM2 expression in the progression of Barrett’s oesophagus
Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amount of interobserver variation. Biomarkers may...
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| Format: | Article |
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Wiley
2018
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| Online Access: | https://eprints.nottingham.ac.uk/49619/ |
| _version_ | 1848798039450320896 |
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| author | Robinson, Leora Ilyas, Mohammad Ragunath, Krish Card, Timothy R. Abradu-Berchie, Berice Kaye, Philip |
| author_facet | Robinson, Leora Ilyas, Mohammad Ragunath, Krish Card, Timothy R. Abradu-Berchie, Berice Kaye, Philip |
| author_sort | Robinson, Leora |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amount of interobserver variation. Biomarkers may aid the diagnosis of dysplasia and may help predict the risk of progression to OAC. Abnormal expression of p53 can be reproducibly detected by immunohistochemistry (IHC) and it is an effective marker of risk of OAC1. There is however still a need for additional early stage markers. |
| first_indexed | 2025-11-14T20:13:26Z |
| format | Article |
| id | nottingham-49619 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:13:26Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-496192020-05-04T19:44:14Z https://eprints.nottingham.ac.uk/49619/ MDM2 expression in the progression of Barrett’s oesophagus Robinson, Leora Ilyas, Mohammad Ragunath, Krish Card, Timothy R. Abradu-Berchie, Berice Kaye, Philip Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amount of interobserver variation. Biomarkers may aid the diagnosis of dysplasia and may help predict the risk of progression to OAC. Abnormal expression of p53 can be reproducibly detected by immunohistochemistry (IHC) and it is an effective marker of risk of OAC1. There is however still a need for additional early stage markers. Wiley 2018-06-30 Article PeerReviewed Robinson, Leora, Ilyas, Mohammad, Ragunath, Krish, Card, Timothy R., Abradu-Berchie, Berice and Kaye, Philip (2018) MDM2 expression in the progression of Barrett’s oesophagus. Histopathology, 72 (7). pp. 1230-1233. ISSN 1365-2559 Barret’s oesophagus; MDM2; p53; Dysplasia http://onlinelibrary.wiley.com/doi/10.1111/his.13480/abstract doi:10.1111/his.13480 doi:10.1111/his.13480 |
| spellingShingle | Barret’s oesophagus; MDM2; p53; Dysplasia Robinson, Leora Ilyas, Mohammad Ragunath, Krish Card, Timothy R. Abradu-Berchie, Berice Kaye, Philip MDM2 expression in the progression of Barrett’s oesophagus |
| title | MDM2 expression in the progression of Barrett’s oesophagus |
| title_full | MDM2 expression in the progression of Barrett’s oesophagus |
| title_fullStr | MDM2 expression in the progression of Barrett’s oesophagus |
| title_full_unstemmed | MDM2 expression in the progression of Barrett’s oesophagus |
| title_short | MDM2 expression in the progression of Barrett’s oesophagus |
| title_sort | mdm2 expression in the progression of barrett’s oesophagus |
| topic | Barret’s oesophagus; MDM2; p53; Dysplasia |
| url | https://eprints.nottingham.ac.uk/49619/ https://eprints.nottingham.ac.uk/49619/ https://eprints.nottingham.ac.uk/49619/ |