Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT₆ receptor
antagonist SB-399885

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Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT₆ receptor antagonist SB-399885

Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT₆ receptor antagonist SB-399885 to reverse isolation-induced cognitive deficits, then investigated alter...

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Bibliographic Details
Main Authors:	Shortall, Sinead E., Negm, Ola H., Fowler, Maxine J., Fairclough, Lucy C., Tighe, Patrick J., Wigmore, Peter, King, Madeleine V.
Format:	Article
Published:	Springer 2018
Subjects:	5-HT₆ receptor social isolation schizophrenia cytokines hippocampus JNK Mitogen-Activated Protein Kinases
Online Access:	https://eprints.nottingham.ac.uk/49554/

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