Insulin-like peptide 3 (INSL3)
Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excellent biomarker for Leydig cell functional capacity, and can be used to m...
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| Format: | Book Section |
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Elsevier, Waltham MA
2018
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| Online Access: | https://eprints.nottingham.ac.uk/49343/ |
| _version_ | 1848797976547295232 |
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| author | Anand-Ivell, Ravinder Ivell, Richard |
| author2 | Huhtaniemi, Ilpo |
| author_facet | Huhtaniemi, Ilpo Anand-Ivell, Ravinder Ivell, Richard |
| author_sort | Anand-Ivell, Ravinder |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excellent biomarker for Leydig cell functional capacity, and can be used to monitor fetal and pubertal development, as well as male ageing. Its major function is to promote the first transabdominal phase of testis descent in the fetus, interacting with RXFP2 receptors on the gubernacular ligaments. It also has functions in the adult linked to spermatogenesis, steroidogenesis and bone metabolism. INSL3 is also produced in the female as a paracrine system within the ovary serving to promote steroidogenesis within growing antral follicles. |
| first_indexed | 2025-11-14T20:12:26Z |
| format | Book Section |
| id | nottingham-49343 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:12:26Z |
| publishDate | 2018 |
| publisher | Elsevier, Waltham MA |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-493432020-04-29T15:59:31Z https://eprints.nottingham.ac.uk/49343/ Insulin-like peptide 3 (INSL3) Anand-Ivell, Ravinder Ivell, Richard Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excellent biomarker for Leydig cell functional capacity, and can be used to monitor fetal and pubertal development, as well as male ageing. Its major function is to promote the first transabdominal phase of testis descent in the fetus, interacting with RXFP2 receptors on the gubernacular ligaments. It also has functions in the adult linked to spermatogenesis, steroidogenesis and bone metabolism. INSL3 is also produced in the female as a paracrine system within the ovary serving to promote steroidogenesis within growing antral follicles. Elsevier, Waltham MA Huhtaniemi, Ilpo Martini, Luciano 2018-01-13 Book Section PeerReviewed Anand-Ivell, Ravinder and Ivell, Richard (2018) Insulin-like peptide 3 (INSL3). In: Encyclopedia of Endocrine Diseases, Second Edition. Elsevier, Waltham MA. (In Press) Insulin-like peptide 3 relaxin RXFP2 cryptorchidism testis descent puberty male ageing Leydig cells testosterone ovarian antral follicles PCOS |
| spellingShingle | Insulin-like peptide 3 relaxin RXFP2 cryptorchidism testis descent puberty male ageing Leydig cells testosterone ovarian antral follicles PCOS Anand-Ivell, Ravinder Ivell, Richard Insulin-like peptide 3 (INSL3) |
| title | Insulin-like peptide 3 (INSL3) |
| title_full | Insulin-like peptide 3 (INSL3) |
| title_fullStr | Insulin-like peptide 3 (INSL3) |
| title_full_unstemmed | Insulin-like peptide 3 (INSL3) |
| title_short | Insulin-like peptide 3 (INSL3) |
| title_sort | insulin-like peptide 3 (insl3) |
| topic | Insulin-like peptide 3 relaxin RXFP2 cryptorchidism testis descent puberty male ageing Leydig cells testosterone ovarian antral follicles PCOS |
| url | https://eprints.nottingham.ac.uk/49343/ |