Branching dendrites with resonant membrane: a "sum-over-trips" approach
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the respo...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Springer
2007
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/493/ |
| _version_ | 1848790419662438400 |
|---|---|
| author | Coombes, Stephen Timofeeva, Yulia Svennson, Carl-Magnus Lord, Gabriel Josic, Kresimir Cox, Steven J. Colbert, Costa |
| author_facet | Coombes, Stephen Timofeeva, Yulia Svennson, Carl-Magnus Lord, Gabriel Josic, Kresimir Cox, Steven J. Colbert, Costa |
| author_sort | Coombes, Stephen |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the response characteristics of a single neuron comes from the intrinsic resonant properties of dendritic membrane. In this paper we combine the effects of dendritic branching and resonant membrane dynamics by generalising the "sum-over-trips" approach [Abbott, L.F., Fahri, E., Gutmann, S.: The path integral for dendritic trees. Biological Cybernetics 66, 49--60 (1991)]. To illustrate how this formalism can shed light on the role of architecture and resonances in determining neuronal output we consider dual recording and reconstruction data from a rat CA1 hippocampal pyramidal cell. Specifically we explore the way in which an $I_{h}$ current contributes to a voltage overshoot at the soma. |
| first_indexed | 2025-11-14T18:12:19Z |
| format | Article |
| id | nottingham-493 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:12:19Z |
| publishDate | 2007 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-4932020-05-04T20:28:27Z https://eprints.nottingham.ac.uk/493/ Branching dendrites with resonant membrane: a "sum-over-trips" approach Coombes, Stephen Timofeeva, Yulia Svennson, Carl-Magnus Lord, Gabriel Josic, Kresimir Cox, Steven J. Colbert, Costa Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the response characteristics of a single neuron comes from the intrinsic resonant properties of dendritic membrane. In this paper we combine the effects of dendritic branching and resonant membrane dynamics by generalising the "sum-over-trips" approach [Abbott, L.F., Fahri, E., Gutmann, S.: The path integral for dendritic trees. Biological Cybernetics 66, 49--60 (1991)]. To illustrate how this formalism can shed light on the role of architecture and resonances in determining neuronal output we consider dual recording and reconstruction data from a rat CA1 hippocampal pyramidal cell. Specifically we explore the way in which an $I_{h}$ current contributes to a voltage overshoot at the soma. Springer 2007-04 Article PeerReviewed Coombes, Stephen, Timofeeva, Yulia, Svennson, Carl-Magnus, Lord, Gabriel, Josic, Kresimir, Cox, Steven J. and Colbert, Costa (2007) Branching dendrites with resonant membrane: a "sum-over-trips" approach. Biological Cybernetics, 97 (2). pp. 137-149. ISSN 0340-1200 dendrites quasi-active membrane "sum-over-trips" cable theory http://www.springerlink.com/content/d463265w2055l123/ doi:10.1007/s00422-007-0161-5 doi:10.1007/s00422-007-0161-5 |
| spellingShingle | dendrites quasi-active membrane "sum-over-trips" cable theory Coombes, Stephen Timofeeva, Yulia Svennson, Carl-Magnus Lord, Gabriel Josic, Kresimir Cox, Steven J. Colbert, Costa Branching dendrites with resonant membrane: a "sum-over-trips" approach |
| title | Branching dendrites with resonant membrane: a "sum-over-trips" approach |
| title_full | Branching dendrites with resonant membrane: a "sum-over-trips" approach |
| title_fullStr | Branching dendrites with resonant membrane: a "sum-over-trips" approach |
| title_full_unstemmed | Branching dendrites with resonant membrane: a "sum-over-trips" approach |
| title_short | Branching dendrites with resonant membrane: a "sum-over-trips" approach |
| title_sort | branching dendrites with resonant membrane: a "sum-over-trips" approach |
| topic | dendrites quasi-active membrane "sum-over-trips" cable theory |
| url | https://eprints.nottingham.ac.uk/493/ https://eprints.nottingham.ac.uk/493/ https://eprints.nottingham.ac.uk/493/ |