Targeting ataxia telangiectasia mutated and Rad3 related kinase (ATR) in PTEN deficient breast cancers for personalized therapy

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Targeting ataxia telangiectasia mutated and Rad3 related kinase (ATR) in PTEN deficient breast cancers for personalized therapy

Purpose: PTEN, a negative regulator of PI3K signaling, is involved in DNA repair. ATR is a key sensor of DNA damage and replication stress. We evaluated whether ATR signaling has clinical significance and could be targeted by synthetic lethality in PTEN deficient triple negative breast cancer (TNBC)...

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Bibliographic Details
Main Authors:	Al-Subhi, Nouf, Ali, Reem, Abdel-Fatah, Tarek, Moseley, Paul M., Chan, Stephen Y.T., Green, Andrew R., Ellis, Ian O., Rakha, Emad, Madhusudan, Srinivasan
Format:	Article
Published:	Springer 2018
Subjects:	Breast cancer; biomarker; PTEN; ATR; Triple negative breast cancer; Synthetic lethality
Online Access:	https://eprints.nottingham.ac.uk/49279/

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