Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial
Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: Multi-centre, mixed-methods feasibility randomized controlled trial of intervention p...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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SAGE
2018
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| Online Access: | https://eprints.nottingham.ac.uk/49261/ |
| _version_ | 1848797959627472896 |
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| author | das Nair, Roshan Mhizha-Murira, Jacqueline R. Anderson, Pippa Carpenter, Hannah Clarke, Simon Groves, Sam Leighton, Paul Scammell, Brigitte E. Topcu, Gogem Walsh, David A. Lincoln, Nadina B. |
| author_facet | das Nair, Roshan Mhizha-Murira, Jacqueline R. Anderson, Pippa Carpenter, Hannah Clarke, Simon Groves, Sam Leighton, Paul Scammell, Brigitte E. Topcu, Gogem Walsh, David A. Lincoln, Nadina B. |
| author_sort | das Nair, Roshan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty.
Design: Multi-centre, mixed-methods feasibility randomized controlled trial of intervention plus usual care versus usual care.
Setting: Participants’ homes or hospital.
Participants: Patients with knee osteoarthritis listed for total knee arthroplasty and score >7 on either subscales of Hospital Anxiety and Depression Scale.
Intervention: Up-to 10 sessions of psychological intervention (based on cognitive behavioural therapy).
Main measures: Feasibility outcomes (recruitment and retention rates, acceptability of trial procedures and intervention, completion of outcome measures), and standardized questionnaires assessing pain, function, and mood at baseline, and four and six months post-randomisation.
Results: Of 222 people screened, 81 did not meet inclusion criteria, 64 did not wish to participate, 26 were excluded for other reasons, and 51 were randomized. A total of 30 completed 4-months outcomes and 25 completed 6-month outcomes. Modal number of intervention sessions completed was three (range 2–8). At six-month follow-up, mood, pain, and physical function scores were consistent with clinically important benefits from intervention, with effect sizes ranging from small (d = 0.005) to moderate (d = 0.74), and significant differences in physical function between intervention and usual care groups (d = 1.16). Feedback interviews suggested that participants understood the rationale for the study, found the information provided adequate, the measures comprehensive, and the intervention acceptable.
Conclusion: A definitive trial is feasible, with a total sample size of 444 people. Pain is a suitable primary outcome, but best assessed 6 and 12 months post-surgery. |
| first_indexed | 2025-11-14T20:12:10Z |
| format | Article |
| id | nottingham-49261 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:12:10Z |
| publishDate | 2018 |
| publisher | SAGE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-492612020-05-04T19:31:47Z https://eprints.nottingham.ac.uk/49261/ Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial das Nair, Roshan Mhizha-Murira, Jacqueline R. Anderson, Pippa Carpenter, Hannah Clarke, Simon Groves, Sam Leighton, Paul Scammell, Brigitte E. Topcu, Gogem Walsh, David A. Lincoln, Nadina B. Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: Multi-centre, mixed-methods feasibility randomized controlled trial of intervention plus usual care versus usual care. Setting: Participants’ homes or hospital. Participants: Patients with knee osteoarthritis listed for total knee arthroplasty and score >7 on either subscales of Hospital Anxiety and Depression Scale. Intervention: Up-to 10 sessions of psychological intervention (based on cognitive behavioural therapy). Main measures: Feasibility outcomes (recruitment and retention rates, acceptability of trial procedures and intervention, completion of outcome measures), and standardized questionnaires assessing pain, function, and mood at baseline, and four and six months post-randomisation. Results: Of 222 people screened, 81 did not meet inclusion criteria, 64 did not wish to participate, 26 were excluded for other reasons, and 51 were randomized. A total of 30 completed 4-months outcomes and 25 completed 6-month outcomes. Modal number of intervention sessions completed was three (range 2–8). At six-month follow-up, mood, pain, and physical function scores were consistent with clinically important benefits from intervention, with effect sizes ranging from small (d = 0.005) to moderate (d = 0.74), and significant differences in physical function between intervention and usual care groups (d = 1.16). Feedback interviews suggested that participants understood the rationale for the study, found the information provided adequate, the measures comprehensive, and the intervention acceptable. Conclusion: A definitive trial is feasible, with a total sample size of 444 people. Pain is a suitable primary outcome, but best assessed 6 and 12 months post-surgery. SAGE 2018-02-09 Article PeerReviewed das Nair, Roshan, Mhizha-Murira, Jacqueline R., Anderson, Pippa, Carpenter, Hannah, Clarke, Simon, Groves, Sam, Leighton, Paul, Scammell, Brigitte E., Topcu, Gogem, Walsh, David A. and Lincoln, Nadina B. (2018) Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial. Clinical Rehabilitation . 026921551875542. ISSN 1477-0873 Psychological intervention total knee arthroplasty knee osteoarthritis randomized controlled trial feasibility http://journals.sagepub.com/doi/10.1177/0269215518755426 doi:10.1177/0269215518755426 doi:10.1177/0269215518755426 |
| spellingShingle | Psychological intervention total knee arthroplasty knee osteoarthritis randomized controlled trial feasibility das Nair, Roshan Mhizha-Murira, Jacqueline R. Anderson, Pippa Carpenter, Hannah Clarke, Simon Groves, Sam Leighton, Paul Scammell, Brigitte E. Topcu, Gogem Walsh, David A. Lincoln, Nadina B. Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial |
| title | Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial |
| title_full | Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial |
| title_fullStr | Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial |
| title_full_unstemmed | Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial |
| title_short | Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial |
| title_sort | home-based pre-surgical psychological intervention for knee osteoarthritis (happiknees): a feasibility randomised controlled trial |
| topic | Psychological intervention total knee arthroplasty knee osteoarthritis randomized controlled trial feasibility |
| url | https://eprints.nottingham.ac.uk/49261/ https://eprints.nottingham.ac.uk/49261/ https://eprints.nottingham.ac.uk/49261/ |