ATNT: an enhanced system for expression of polycistronic secondary metabolite gene clusters in Aspergillus niger

QR Code

ATNT: an enhanced system for expression of polycistronic secondary metabolite gene clusters in Aspergillus niger

Background: Fungi are treasure chests for yet unexplored natural products. However, exploitation of their real potential remains difficult as a significant proportion of biosynthetic gene clusters appears silent under standard laboratory conditions. Therefore, elucidation of novel products requires...

Full description

Bibliographic Details
Main Authors:	Geib, Elena, Brock, Matthias
Format:	Article
Published:	BioMed Central 2017
Subjects:	Asp-melaninP2A ; Polycistronic mRNA ; Tet-on system ; Doxycycline ; Terrein biosynthetic gene cluster
Online Access:	https://eprints.nottingham.ac.uk/49165/

Similar Items

Characterisation and Intercellular Mechanistic Analysis of Supramolecular, Cationic, mRNA-Loaded Polyplexes for Efficient Transfection in HEK293T and A549 Cells
by: Smith, Silvia
Published: (2023)

Exploitation of a novel heterologous expression system for characterisation of fungal secondary metabolites
by: Geib, Elena
Published: (2018)

Molecular biology approaches to quantify subcellular localisation of mRNA therapeutics
by: Smart, Alfredo D.
Published: (2025)

Part A: RNA Therapeutics. Development and challenges in nanoparticle delivery/ Part B: Synthesis and characterisation of supramolecular polyplexes for mRNA delivery
by: Vasudevan, Akshaya
Published: (2024)

Investigation of melanogenesis using neonatal normal human epidermal melanocyte treated with mawa young coconut water
by: Ansari, Sara
Published: (2015)

Sugar-coated nanoparticles: Investigating lipid-terminated glycopolymers for targeted nanoparticle delivery of nucleic acids
by: Fiedler, Benjamin
Published: (2024)

The dynamic role of mRNA m6A methylation in Arabidopsis thaliana and Solanum lycopersicum
by: Chak, Samuel Erwin Seng Chung
Published: (2024)

Reconstitution of the Core Ccr4-Not Complex and Evidence for Possible Interaction between YTHDF2 and Human CNOT9
by: Gong, Yutong
Published: (2025)

Inhibition of melanogenic activity by chalcone derivatives in alpha-melanocyte stimulating hormone cell line (B16-F10)
by: Mohd Sakeh, Nurshafika
Published: (2014)

Hippocampal TET1 and TET2 expression and DNA hydroxymethylation are affected by physical exercise in aged mice
by: Jessop, Peter, et al.
Published: (2018)

Polymorphisms detected in the tyrosinase and matp (slc45a2) genes did not explain coat colour dilution in a sample of Alpaca (Vicugna pacos)
by: Cransberg, R., et al.
Published: (2011)

Investigation of the PABPC1-BTG2 interaction and its effects on mRNA deadenylation by CNOT7(CAF1)
by: Ameerul Moominin, Aalam Mohammed
Published: (2022)

RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger
by: Archer, David B.
Published: (2014)

Transcriptional landscape of Aspergillus niger at breaking of conidial dormancy revealed by RNA-sequencing
by: Novodvorska, Michaela, et al.
Published: (2013)

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation
by: Soukarieh, Fadi, et al.
Published: (2016)

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module
by: Maryati, Marayti, et al.
Published: (2015)

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster
by: Gressler, Markus, et al.
Published: (2015)

Development of existing and novel tyrosinase inhibitors for skin pigmentation: intradermal delivery, biological evaluation and mechanistic studies
by: Li, Zhiwei
Published: (2023)

A genomics-based discovery pipeline for Pseudomonas derived antifungals effective against the wheat pathogen Zymoseptoria tritici
by: Lund, George
Published: (2023)

Identification and characterization of genes involved in the fruit color development of european plum
by: Selvaraj, Dineshkumar, et al.
Published: (2016)

Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
by: Růžička, Kamil, et al.
Published: (2017)

Investigating the role of eIF4A2 in the spatial regulation of metabolic adaptation to hypoxia in colorectal cancer
by: Thornton, Luke
Published: (2023)

Alternative RNA splicing: contribution to pain and potential therapeutic strategy
by: Donaldson, Lucy F., et al.
Published: (2016)

The role of Tet2 and Tet3 in the molecular programming of blood cell differentiation during zebrafish development
by: Alayed, Amal Saeed M
Published: (2025)

Transcriptional analysis of Bdellovibrio bacteriovorus responses to different prey and environments
by: Lambert, Carey
Published: (2022)

Expression of Aspergillus niger CAZymes is determined by compositional changes in wheat straw generated by hydrothermal or ionic liquid pretreatments
by: Daly, Paul, et al.
Published: (2017)

Characterization of miR-3099-mediated posttranscriptional of target genes regulation during neurogenesis in mice
by: Zainal Abidin, Shahidee
Published: (2019)

Germination of Aspergillus niger conidia
by: Hayer, Kimran
Published: (2014)

Identifying potential RNA editing sites from RNA-Sequencing data from human brain tissue
by: North, Francesca Louise
Published: (2018)

Axon pathology in mouse models of Huntington's disease
by: Marangoni, Martina
Published: (2014)

Biosynthetic origin of the saw-toothed profile in d13C and d2Y of n-alkanes and systematic isotopic differences between n-, iso- and anteiso-alkanes in leaf waxes of land plants
by: Zhou, Y., et al.
Published: (2010)

A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress
by: Geib, Elena, et al.
Published: (2016)

Biosynthesis of selenium nanoparticles by Aspergillus niger
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2016)

Expression of glycoside hydrolases in Aspergillus niger
by: Raulo, Roxane
Published: (2016)

Development of delayed ripening papaya (Carica papaya L.) CV. 'eksotika' using RNA interference and antisense technologies
by: Sekeli, Rogayah
Published: (2013)

The condition and effects of evolutionary education in the parochial school
by: Schulteis, Michael
Published: (2005)

Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin – The case of the fungal metabolite atromentin
by: Dellafiora, Luca, et al.
Published: (2019)

Production of zinc nanoparticles using Aspergillus Niger
by: Ariffin, Ainnur Farhana, et al.
Published: (2014)

Use of Aspergillus niger to landfill leachate treatment
by: Fakhru'l-Razi, Ahmadun, et al.
Published: (2002)

Biological synthesis of zinc nanoparticles by aspergillus niger
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2014)