Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery
A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this method tackles this problem for the first time allow...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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American Chemical Society
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/49114/ |
| _version_ | 1848797924953161728 |
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| author | Louzao, Iria Koch, Britta Taresco, Vincenzo Ruiz Cantu, Laura Irvine, Derek J. Roberts, Clive J. Tuck, Christopher J. Alexander, Cameron Hague, Richard J.M. Wildman, Ricky D. Alexander, Morgan R. |
| author_facet | Louzao, Iria Koch, Britta Taresco, Vincenzo Ruiz Cantu, Laura Irvine, Derek J. Roberts, Clive J. Tuck, Christopher J. Alexander, Cameron Hague, Richard J.M. Wildman, Ricky D. Alexander, Morgan R. |
| author_sort | Louzao, Iria |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this method tackles this problem for the first time allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity and printability are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties. The selected candidates with the desirable properties are successfully scaled up using 3D printing into a range of objects architectures. A full drug release study, degradability and tensile modulus experiments are presented on a simple architecture to validating the suitability of this methodology to identify printable inks for 3D printing devices with bespoke properties. |
| first_indexed | 2025-11-14T20:11:37Z |
| format | Article |
| id | nottingham-49114 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:11:37Z |
| publishDate | 2018 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-491142020-05-04T19:26:19Z https://eprints.nottingham.ac.uk/49114/ Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery Louzao, Iria Koch, Britta Taresco, Vincenzo Ruiz Cantu, Laura Irvine, Derek J. Roberts, Clive J. Tuck, Christopher J. Alexander, Cameron Hague, Richard J.M. Wildman, Ricky D. Alexander, Morgan R. A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this method tackles this problem for the first time allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity and printability are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties. The selected candidates with the desirable properties are successfully scaled up using 3D printing into a range of objects architectures. A full drug release study, degradability and tensile modulus experiments are presented on a simple architecture to validating the suitability of this methodology to identify printable inks for 3D printing devices with bespoke properties. American Chemical Society 2018-01-11 Article PeerReviewed Louzao, Iria, Koch, Britta, Taresco, Vincenzo, Ruiz Cantu, Laura, Irvine, Derek J., Roberts, Clive J., Tuck, Christopher J., Alexander, Cameron, Hague, Richard J.M., Wildman, Ricky D. and Alexander, Morgan R. (2018) Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery. ACS Applied Materials & Interfaces, 10 (8). pp. 6841-6848. ISSN 1944-8244 3D printing Drug Delivery Polymer materials Biomedical devices Sustained drug release https://pubs.acs.org/doi/10.1021/acsami.7b15677 doi:10.1021/acsami.7b15677 doi:10.1021/acsami.7b15677 |
| spellingShingle | 3D printing Drug Delivery Polymer materials Biomedical devices Sustained drug release Louzao, Iria Koch, Britta Taresco, Vincenzo Ruiz Cantu, Laura Irvine, Derek J. Roberts, Clive J. Tuck, Christopher J. Alexander, Cameron Hague, Richard J.M. Wildman, Ricky D. Alexander, Morgan R. Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery |
| title | Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery |
| title_full | Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery |
| title_fullStr | Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery |
| title_full_unstemmed | Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery |
| title_short | Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery |
| title_sort | identification of novel ‘inks’ for 3d printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery |
| topic | 3D printing Drug Delivery Polymer materials Biomedical devices Sustained drug release |
| url | https://eprints.nottingham.ac.uk/49114/ https://eprints.nottingham.ac.uk/49114/ https://eprints.nottingham.ac.uk/49114/ |