Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials
Abstract. Vietnam is participating in a global de-worming effort that aims to treat 650 million school children regularly by 2010. The treatment used in Vietnam is single dose oral mebendazole (Phardazone®) 500 mg. We tested the efficacy of single dose mebendazole 500 mg in the therapy of hookworm i...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Society of Tropical Medicine and Hygiene
2007
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/491/ |
| _version_ | 1848790419326894080 |
|---|---|
| author | Carsten, Flohr Luc, Nguyen Tuyen Sarah, Lewis Truong, Tan Minh Jim, Campbell John, Britton Hywel, Williams Tran, Tinh Hien Jeremy, Farrar Rupert J., Quinnell |
| author_facet | Carsten, Flohr Luc, Nguyen Tuyen Sarah, Lewis Truong, Tan Minh Jim, Campbell John, Britton Hywel, Williams Tran, Tinh Hien Jeremy, Farrar Rupert J., Quinnell |
| author_sort | Carsten, Flohr |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Abstract. Vietnam is participating in a global de-worming effort that aims to treat 650 million school children regularly by 2010. The treatment used in Vietnam is single dose oral mebendazole (Phardazone®) 500 mg. We tested the efficacy of single dose mebendazole 500 mg in the therapy of hookworm infection in a randomized double-blind placebo-controlled trial among 271 Vietnamese schoolchildren. The treatment efficacy of single dose mebendazole in children did not differ significantly from placebo, with a reduction in mean eggs per gram of feces relative to placebo of 31% (95% CI - �9 to 56%, P = 0.1). In light of these findings we then carried out a similar randomized trial comparing triple dose mebendazole, single dose albendazole, and triple dose albendazole against placebo in 209 adults in the same area. The estimated reduction in mean post-treatment eggs per gram of feces relative to placebo was 63% (95% CI 30 - 81%) for triple mebendazole, 75% (47 - 88%) for single albendazole, and 88% (58Ã - 97%) for triple albendazole. Our results suggest that single dose oral mebendazole has low efficacy against hookworm infection in Vietnam, and that it should be replaced by albendazole. These findings are of major public health relevance given the opportunity costs of treating entire populations with ineffective therapies. We recommend that efficacy of anti-helminth therapies is pilot tested before implementation of national gut worm control programs. |
| first_indexed | 2025-11-14T18:12:19Z |
| format | Article |
| id | nottingham-491 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T18:12:19Z |
| publishDate | 2007 |
| publisher | American Society of Tropical Medicine and Hygiene |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-4912021-05-31T14:47:46Z https://eprints.nottingham.ac.uk/491/ Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials Carsten, Flohr Luc, Nguyen Tuyen Sarah, Lewis Truong, Tan Minh Jim, Campbell John, Britton Hywel, Williams Tran, Tinh Hien Jeremy, Farrar Rupert J., Quinnell Abstract. Vietnam is participating in a global de-worming effort that aims to treat 650 million school children regularly by 2010. The treatment used in Vietnam is single dose oral mebendazole (Phardazone®) 500 mg. We tested the efficacy of single dose mebendazole 500 mg in the therapy of hookworm infection in a randomized double-blind placebo-controlled trial among 271 Vietnamese schoolchildren. The treatment efficacy of single dose mebendazole in children did not differ significantly from placebo, with a reduction in mean eggs per gram of feces relative to placebo of 31% (95% CI - �9 to 56%, P = 0.1). In light of these findings we then carried out a similar randomized trial comparing triple dose mebendazole, single dose albendazole, and triple dose albendazole against placebo in 209 adults in the same area. The estimated reduction in mean post-treatment eggs per gram of feces relative to placebo was 63% (95% CI 30 - 81%) for triple mebendazole, 75% (47 - 88%) for single albendazole, and 88% (58Ã - 97%) for triple albendazole. Our results suggest that single dose oral mebendazole has low efficacy against hookworm infection in Vietnam, and that it should be replaced by albendazole. These findings are of major public health relevance given the opportunity costs of treating entire populations with ineffective therapies. We recommend that efficacy of anti-helminth therapies is pilot tested before implementation of national gut worm control programs. American Society of Tropical Medicine and Hygiene 2007-04 Article NonPeerReviewed application/pdf en https://eprints.nottingham.ac.uk/491/1/Am_J_Trop_Med_Hyg_Low_efficacy_of_mebendazole_Flohr_et_al.pdf Carsten, Flohr, Luc, Nguyen Tuyen, Sarah, Lewis, Truong, Tan Minh, Jim, Campbell, John, Britton, Hywel, Williams, Tran, Tinh Hien, Jeremy, Farrar and Rupert J., Quinnell (2007) Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials. American Journal of Tropical Medicine and Hygiene, 76 (4). pp. 732-736. ISSN 0002-9637 hookworm mebendazole http://www.ajtmh.org/ |
| spellingShingle | hookworm mebendazole Carsten, Flohr Luc, Nguyen Tuyen Sarah, Lewis Truong, Tan Minh Jim, Campbell John, Britton Hywel, Williams Tran, Tinh Hien Jeremy, Farrar Rupert J., Quinnell Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials |
| title | Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials |
| title_full | Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials |
| title_fullStr | Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials |
| title_full_unstemmed | Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials |
| title_short | Low efficacy of Mebendazole Against Hookworm in Vietman: Two Randomized Controlled Trials |
| title_sort | low efficacy of mebendazole against hookworm in vietman: two randomized controlled trials |
| topic | hookworm mebendazole |
| url | https://eprints.nottingham.ac.uk/491/ https://eprints.nottingham.ac.uk/491/ |