Amygdala subnuclei response and connectivity during emotional processing
The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emoti...
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/49070/ |
| _version_ | 1848797914978058240 |
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| author | Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V. |
| author_facet | Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V. |
| author_sort | Hrybouski, Stanislau |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emotions. Here we combined a novel anatomical tracing protocol with event-related high-resolution fMRI acquisition to study the responsiveness of the amygdala subnuclei to negative emotional stimuli and to examine intra-amygdala functional connectivity. The greatest sensitivity to the negative emotional stimuli was observed in the centromedial amygdala, where the hemodynamic response amplitude elicited by the negative emotional stimuli was greater and peaked later than for neutral stimuli. Connectivity patterns converge with extant findings in animals, such that the centromedial amygdala was more connected with the nuclei of the basal amygdala than with the lateral amygdala. Current findings provide evidence of functional specialization within the human amygdala. |
| first_indexed | 2025-11-14T20:11:27Z |
| format | Article |
| id | nottingham-49070 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:11:27Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-490702020-05-04T17:54:34Z https://eprints.nottingham.ac.uk/49070/ Amygdala subnuclei response and connectivity during emotional processing Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V. The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emotions. Here we combined a novel anatomical tracing protocol with event-related high-resolution fMRI acquisition to study the responsiveness of the amygdala subnuclei to negative emotional stimuli and to examine intra-amygdala functional connectivity. The greatest sensitivity to the negative emotional stimuli was observed in the centromedial amygdala, where the hemodynamic response amplitude elicited by the negative emotional stimuli was greater and peaked later than for neutral stimuli. Connectivity patterns converge with extant findings in animals, such that the centromedial amygdala was more connected with the nuclei of the basal amygdala than with the lateral amygdala. Current findings provide evidence of functional specialization within the human amygdala. Elsevier 2016-06-30 Article PeerReviewed Hrybouski, Stanislau, Aghamohammadi-Sereshki, Arash, Madan, Christopher R., Shafer, Andrea T., Baron, Corey A., Seres, Peter, Beaulieu, Christian, Olsen, Fraser and Malykhin, Nikolai V. (2016) Amygdala subnuclei response and connectivity during emotional processing. NeuroImage, 133 . pp. 98-110. ISSN 1095-9572 High-resolution fMRI; Amygdala subnuclei; Amygdala connectivity; Emotions http://www.sciencedirect.com/science/article/pii/S1053811916001658 doi:10.1016/j.neuroimage.2016.02.056 doi:10.1016/j.neuroimage.2016.02.056 |
| spellingShingle | High-resolution fMRI; Amygdala subnuclei; Amygdala connectivity; Emotions Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V. Amygdala subnuclei response and connectivity during emotional processing |
| title | Amygdala subnuclei response and connectivity during emotional processing |
| title_full | Amygdala subnuclei response and connectivity during emotional processing |
| title_fullStr | Amygdala subnuclei response and connectivity during emotional processing |
| title_full_unstemmed | Amygdala subnuclei response and connectivity during emotional processing |
| title_short | Amygdala subnuclei response and connectivity during emotional processing |
| title_sort | amygdala subnuclei response and connectivity during emotional processing |
| topic | High-resolution fMRI; Amygdala subnuclei; Amygdala connectivity; Emotions |
| url | https://eprints.nottingham.ac.uk/49070/ https://eprints.nottingham.ac.uk/49070/ https://eprints.nottingham.ac.uk/49070/ |