Transaminases for chiral amine synthesis
Amine transaminases are important biocatalysts for the synthesis of chiral primary amines. Unlike many enzymes that have been employed for the synthesis of optically active amines, amine transaminases are capable of asymmetric synthesis and do not rely on costly cofactors that must be regenerated in...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | https://eprints.nottingham.ac.uk/49054/ |
| _version_ | 1848797912507613184 |
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| author | Gomm, Andrew O'Reilly, Elaine |
| author_facet | Gomm, Andrew O'Reilly, Elaine |
| author_sort | Gomm, Andrew |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Amine transaminases are important biocatalysts for the synthesis of chiral primary amines. Unlike many enzymes that have been employed for the synthesis of optically active amines, amine transaminases are capable of asymmetric synthesis and do not rely on costly cofactors that must be regenerated in situ. However, their application as general catalysts for the preparation of amines is hampered by a limited substrate scope, substrate and (co)product inhibition and difficulties associated with displacing challenging reaction equilibrium. There has been important progress made to overcome these challenges, including the development of enzymes with broader substrate scope and the design of methodology to effectively displace the reaction equilibrium. Amine transaminases are also being applied in an increasing range of (chemo)enzymatic cascades and immobilized for applications in flow. |
| first_indexed | 2025-11-14T20:11:25Z |
| format | Article |
| id | nottingham-49054 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:11:25Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-490542020-05-04T19:51:50Z https://eprints.nottingham.ac.uk/49054/ Transaminases for chiral amine synthesis Gomm, Andrew O'Reilly, Elaine Amine transaminases are important biocatalysts for the synthesis of chiral primary amines. Unlike many enzymes that have been employed for the synthesis of optically active amines, amine transaminases are capable of asymmetric synthesis and do not rely on costly cofactors that must be regenerated in situ. However, their application as general catalysts for the preparation of amines is hampered by a limited substrate scope, substrate and (co)product inhibition and difficulties associated with displacing challenging reaction equilibrium. There has been important progress made to overcome these challenges, including the development of enzymes with broader substrate scope and the design of methodology to effectively displace the reaction equilibrium. Amine transaminases are also being applied in an increasing range of (chemo)enzymatic cascades and immobilized for applications in flow. Elsevier 2018-04 Article PeerReviewed Gomm, Andrew and O'Reilly, Elaine (2018) Transaminases for chiral amine synthesis. Current Opinion in Chemical Biology, 43 . pp. 106-112. ISSN 1879-0402 https://www.sciencedirect.com/science/article/pii/S1367593117301734 doi:10.1016/j.cbpa.2017.12.007 doi:10.1016/j.cbpa.2017.12.007 |
| spellingShingle | Gomm, Andrew O'Reilly, Elaine Transaminases for chiral amine synthesis |
| title | Transaminases for chiral amine synthesis |
| title_full | Transaminases for chiral amine synthesis |
| title_fullStr | Transaminases for chiral amine synthesis |
| title_full_unstemmed | Transaminases for chiral amine synthesis |
| title_short | Transaminases for chiral amine synthesis |
| title_sort | transaminases for chiral amine synthesis |
| url | https://eprints.nottingham.ac.uk/49054/ https://eprints.nottingham.ac.uk/49054/ https://eprints.nottingham.ac.uk/49054/ |