A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis
Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Public Library of Science
2017
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| Online Access: | https://eprints.nottingham.ac.uk/49028/ |
| _version_ | 1848797906887245824 |
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| author | Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin |
| author_facet | Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin |
| author_sort | Gao, Yi-Qun |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general. |
| first_indexed | 2025-11-14T20:11:19Z |
| format | Article |
| id | nottingham-49028 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:11:19Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-490282020-05-04T19:24:02Z https://eprints.nottingham.ac.uk/49028/ A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general. Public Library of Science 2017-12-28 Article PeerReviewed Gao, Yi-Qun, Chen, Jiu-Geng, Chen, Zi-Ru, An, Dong, Lv, Qiao-Yan, Han, Mei-Ling, Wang, Ya-Ling, Salt, David E. and Chao, Dai-Yin (2017) A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis. PLoS Biology, 15 (12). e2002978/1-e2002978/27. ISSN 1545-7885 http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002978 doi:10.1371/journal.pbio.2002978 doi:10.1371/journal.pbio.2002978 |
| spellingShingle | Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
| title | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
| title_full | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
| title_fullStr | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
| title_full_unstemmed | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
| title_short | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
| title_sort | new vesicle trafficking regulator ctl1 plays a crucial role in ion homeostasis |
| url | https://eprints.nottingham.ac.uk/49028/ https://eprints.nottingham.ac.uk/49028/ https://eprints.nottingham.ac.uk/49028/ |