Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study
Rationale: Studies suggest that people with bronchiectasis are at increased risk of cardiovascular co-morbidities. Objectives: We aimed to quantify the relative risk of incident cardiovascular events following a respiratory tract infection amongst people with bronchiectasis. Methods: Using U...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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American Thoracic Society
2018
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| Online Access: | https://eprints.nottingham.ac.uk/49007/ |
| _version_ | 1848797900904071168 |
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| author | Navaratnam, Vidya Root, Adrian A Douglas, Ian Smeeth, Liam Hubbard, Richard B. Quint, Jennifer K. |
| author_facet | Navaratnam, Vidya Root, Adrian A Douglas, Ian Smeeth, Liam Hubbard, Richard B. Quint, Jennifer K. |
| author_sort | Navaratnam, Vidya |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Rationale: Studies suggest that people with bronchiectasis are at increased risk of cardiovascular co-morbidities.
Objectives: We aimed to quantify the relative risk of incident cardiovascular events following a respiratory tract infection amongst people with bronchiectasis.
Methods: Using UK electronic primary care records, we conducted a within-person comparison using the self-controlled case series method. We calculated the relative risk of first time cardiovascular events (either first myocardial infarction [MI] or stroke) following a respiratory tract infection compared with the individual’s baseline risk.
Results: Our cohort consisted of 895 individuals with non-CF bronchiectasis with a first MI or stroke and at least one respiratory tract infection. There was an increased rate of first time cardiovascular events in the 91 day period after a respiratory tract infection (Incidence Rate Ratio [IRR] 1.56; 95% CI 1.20 to 2.02). The rate of a first cardiovascular event was highest in the first three days following a respiratory tract infection (IRR 2.73, 95% CI 1.41 to 5.27).
Conclusions: These data suggest that respiratory tract infections are strongly associated with a transient increased risk of first time MI or stroke amongst people with bronchiectasis. As respiratory tract infections are six times more common in people with bronchiectasis than the general population, the increased risk has a disproportionately greater impact in these individuals. These findings may have implications for including cardiovascular risk modifications in airway infection treatment pathways in this population. |
| first_indexed | 2025-11-14T20:11:14Z |
| format | Article |
| id | nottingham-49007 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:11:14Z |
| publishDate | 2018 |
| publisher | American Thoracic Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-490072018-03-14T09:26:34Z https://eprints.nottingham.ac.uk/49007/ Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study Navaratnam, Vidya Root, Adrian A Douglas, Ian Smeeth, Liam Hubbard, Richard B. Quint, Jennifer K. Rationale: Studies suggest that people with bronchiectasis are at increased risk of cardiovascular co-morbidities. Objectives: We aimed to quantify the relative risk of incident cardiovascular events following a respiratory tract infection amongst people with bronchiectasis. Methods: Using UK electronic primary care records, we conducted a within-person comparison using the self-controlled case series method. We calculated the relative risk of first time cardiovascular events (either first myocardial infarction [MI] or stroke) following a respiratory tract infection compared with the individual’s baseline risk. Results: Our cohort consisted of 895 individuals with non-CF bronchiectasis with a first MI or stroke and at least one respiratory tract infection. There was an increased rate of first time cardiovascular events in the 91 day period after a respiratory tract infection (Incidence Rate Ratio [IRR] 1.56; 95% CI 1.20 to 2.02). The rate of a first cardiovascular event was highest in the first three days following a respiratory tract infection (IRR 2.73, 95% CI 1.41 to 5.27). Conclusions: These data suggest that respiratory tract infections are strongly associated with a transient increased risk of first time MI or stroke amongst people with bronchiectasis. As respiratory tract infections are six times more common in people with bronchiectasis than the general population, the increased risk has a disproportionately greater impact in these individuals. These findings may have implications for including cardiovascular risk modifications in airway infection treatment pathways in this population. American Thoracic Society 2018-03-01 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/49007/1/sccs_submitted_revised_clean.pdf Navaratnam, Vidya, Root, Adrian A, Douglas, Ian, Smeeth, Liam, Hubbard, Richard B. and Quint, Jennifer K. (2018) Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study. Annals of the American Thoracic Society, 15 (3). pp. 315-321. ISSN 2325-6621 Bronchiectasis cardiovascular disease myocardial infarction stroke epidemiology self-controlled case series http://www.atsjournals.org/doi/10.1513/AnnalsATS.201706-488OC doi:10.1513/AnnalsATS.201706-488OC doi:10.1513/AnnalsATS.201706-488OC |
| spellingShingle | Bronchiectasis cardiovascular disease myocardial infarction stroke epidemiology self-controlled case series Navaratnam, Vidya Root, Adrian A Douglas, Ian Smeeth, Liam Hubbard, Richard B. Quint, Jennifer K. Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study |
| title | Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study |
| title_full | Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study |
| title_fullStr | Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study |
| title_full_unstemmed | Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study |
| title_short | Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study |
| title_sort | cardiovascular outcomes following a respiratory tract infection among adults with non-cf bronchiectasis: a general population based study |
| topic | Bronchiectasis cardiovascular disease myocardial infarction stroke epidemiology self-controlled case series |
| url | https://eprints.nottingham.ac.uk/49007/ https://eprints.nottingham.ac.uk/49007/ https://eprints.nottingham.ac.uk/49007/ |