Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis
Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience network (SN). The interrelation and possible mech...
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Lippincott, Williams & Wilkins
2018
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| Online Access: | https://eprints.nottingham.ac.uk/49002/ |
| _version_ | 1848797899810406400 |
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| author | Cottam, William J. Iwabuchi, Sarina J. Drabek, Marianne M. Reckziegel, Diane Auer, Dorothee P. |
| author_facet | Cottam, William J. Iwabuchi, Sarina J. Drabek, Marianne M. Reckziegel, Diane Auer, Dorothee P. |
| author_sort | Cottam, William J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience network (SN). The interrelation and possible mechanisms of these changes are less well understood in chronic pain. Based on emerging evidence of its role to drive switches between network states, the right anterior insula (rAI, an SN hub) may play a dominant role in network connectivity changes underpinning chronic pain. To test this hypothesis, we used seed-based resting-state FC analysis including dynamic and effective connectivity metrics in 25 people with chronic osteoarthritis (OA) pain and 19 matched healthy volunteers. Compared to controls, participants with painful knee OA presented with increased anticorrelation between the right anterior insula (SN) and DMN regions. Also, the left dorsal prefrontal cortex (CEN hub) showed more negative FC with the right temporal gyrus. Granger causality analysis revealed increased negative influence of the right anterior insula on the posterior cingulate (DMN) in OA patients in line with the observed enhanced anticorrelation. Moreover, dynamic FC was lower in the DMN of patients and thus more similar to temporal dynamics of the SN. Together, these findings evidence a widespread network disruption in patients with persistent osteoarthritis pain, and point toward a driving role of the rAI. |
| first_indexed | 2025-11-14T20:11:13Z |
| format | Article |
| id | nottingham-49002 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:11:13Z |
| publishDate | 2018 |
| publisher | Lippincott, Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-490022020-05-04T19:35:13Z https://eprints.nottingham.ac.uk/49002/ Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis Cottam, William J. Iwabuchi, Sarina J. Drabek, Marianne M. Reckziegel, Diane Auer, Dorothee P. Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience network (SN). The interrelation and possible mechanisms of these changes are less well understood in chronic pain. Based on emerging evidence of its role to drive switches between network states, the right anterior insula (rAI, an SN hub) may play a dominant role in network connectivity changes underpinning chronic pain. To test this hypothesis, we used seed-based resting-state FC analysis including dynamic and effective connectivity metrics in 25 people with chronic osteoarthritis (OA) pain and 19 matched healthy volunteers. Compared to controls, participants with painful knee OA presented with increased anticorrelation between the right anterior insula (SN) and DMN regions. Also, the left dorsal prefrontal cortex (CEN hub) showed more negative FC with the right temporal gyrus. Granger causality analysis revealed increased negative influence of the right anterior insula on the posterior cingulate (DMN) in OA patients in line with the observed enhanced anticorrelation. Moreover, dynamic FC was lower in the DMN of patients and thus more similar to temporal dynamics of the SN. Together, these findings evidence a widespread network disruption in patients with persistent osteoarthritis pain, and point toward a driving role of the rAI. Lippincott, Williams & Wilkins 2018-05-01 Article PeerReviewed Cottam, William J., Iwabuchi, Sarina J., Drabek, Marianne M., Reckziegel, Diane and Auer, Dorothee P. (2018) Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. PAIN, 159 (5). pp. 929-938. ISSN 1872-6623 Chronic pain; Resting-state; Knee osteoarthritis; Neuroimaging; Functional connectivity https://insights.ovid.com/crossref?an=00006396-201805000-00012 doi:10.1097/j.pain.0000000000001209 doi:10.1097/j.pain.0000000000001209 |
| spellingShingle | Chronic pain; Resting-state; Knee osteoarthritis; Neuroimaging; Functional connectivity Cottam, William J. Iwabuchi, Sarina J. Drabek, Marianne M. Reckziegel, Diane Auer, Dorothee P. Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis |
| title | Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis |
| title_full | Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis |
| title_fullStr | Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis |
| title_full_unstemmed | Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis |
| title_short | Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis |
| title_sort | altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis |
| topic | Chronic pain; Resting-state; Knee osteoarthritis; Neuroimaging; Functional connectivity |
| url | https://eprints.nottingham.ac.uk/49002/ https://eprints.nottingham.ac.uk/49002/ https://eprints.nottingham.ac.uk/49002/ |