UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery

QR Code

UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides. In this study we sought to investigate whether P2Y14 rec...

Full description

Bibliographic Details
Main Authors:	Abbas, Zainab S.B., Liaque Latif, M., Dovlatova, Natalia, Fox, Sue C., Heptinstall, Stan, Dunn, William R., Ralevic, Vera
Format:	Article
Published:	Elsevier 2018
Subjects:	Coronary artery; P2Y6 receptor; P2Y14 receptor; UDP-glucose; UDP sugars; MRS2690; Sugar nucleotides
Online Access:	https://eprints.nottingham.ac.uk/48996/

Similar Items

Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries
by: Alsaqati, M., et al.
Published: (2014)

Identification and characterisation of the P2Y14 purine receptor in the porcine coronary artery
by: Abbas, Z.S.B
Published: (2017)

Characterisation of responses to PGE2-G in the porcine coronary artery, rat aorta and murine microglial cell line BV-2
by: Vadgama, Anisha
Published: (2019)

Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries
by: Alsaqati, M., et al.
Published: (2014)

Design, Synthesis, and Evaluation of New P2Y2 Receptor Antagonists and Fluorescent Ligands
by: Knight, Rebecca
Published: (2025)

Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925
by: Conroy, Sean, et al.
Published: (2018)

Effects of NAD at purine receptors in isolated blood vessels
by: Alefishat, Eman, et al.
Published: (2015)

PAMFix, a fixative developed to enable remote platelet function testing: uses and applications
by: Heptinstall, Stan, et al.
Published: (2015)

Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed
by: Shatarat, Amjad, et al.
Published: (2014)

From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor
by: Kindon, Nicholas, et al.
Published: (2017)

Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15
by: Liu, Mengjie, et al.
Published: (2016)

Biological significance of human epidermal growth factor receptor 2 (HER2) in breast cancer: effect of oestrogen receptor
by: Ahmad, Dena Akram Jerjees
Published: (2016)

A review of recent evidence relating to sugars, insulin resistance and diabetes
by: MacDonald, Ian A.
Published: (2016)

Novel strategies for assessing platelet reactivity
by: Algahtani, Mohammad, et al.
Published: (2017)

Molecular mobility and interactions in biopolymer-sugar-water systems
by: Farhat, Imad Akil
Published: (1996)

Production Of Sugars From Sago Hampas By Trichoderma Sp. During Solid Substrate Fermentation
by: Shahrim, Zaizuhana
Published: (2006)

Association behaviour and rheology of palm based emulsion using mixed sugar based emulsifiers
by: Ismail, Zahariah
Published: (2001)

Purification, Characterization and Molecular Studies of Fructose-6-Phosphate Phosphoketolase (F6PPK) from Bifidobacteria
by: Daifalla Fandi, Khalid Ghazi
Published: (2001)

Effects of curcumin analogue, 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone (BDMC33) on the activities of drug-metabolizing enzymes in cultured Caco-2 cell model
by: Yakubu, Ndatsu, et al.
Published: (2016)

Effects of sugar types and organic acids used on heterocylic amines (HCAs) formation in marinated chicken satay
by: Hasnol, Nur Diyana Syamim
Published: (2014)

Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors
by: Kilpatrick, Laura E., et al.
Published: (2012)

Physiological differences between sugar beet varieties susceptible, tolerant or resistant to the beet cyst nematode, Heterodera schachtii (Schmidt) under uninfested conditions
by: Wright, Alistair J.D., et al.
Published: (2018)

Characterization and development of sugar palm-filled phenolic composites as friction materials
by: Mohammed, Bushra Rashid
Published: (2017)

Bacterial cellulose production from extracted date syrup
by: Lotfiman, Samaneh
Published: (2010)

Enhancement of physical properties of sugar palm (arenga pinnata merr.) fibre-reinforced unsatured polyester composite via vacum resin impregnation
by: Ishak, Mohamad Ridzwan
Published: (2012)

Properties of sugar palm/glass fibre-reinforced thermoplastic polyurethane composites
by: Mohd Afdzaluddin, Atiqah
Published: (2018)

Development and characterisation of sugar palm [Arenga pinnata (Wurmb) Merr.] fibre reinforced vinyl ester composites
by: Mohd Roslim, Muhammad Huzaifah
Published: (2019)

The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization
by: Salazar, Fabián, et al.
Published: (2016)

Public health strategies to reduce sugar intake in the UK: an exploration of public perceptions using digital spaces
by: Swift, J.A., et al.
Published: (2018)

Characterisation of endogenous A2A and A2B receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: evidence for an allosteric mechanism of action for the A2B-selective antagonist PSB 603
by: Goulding, Joelle, et al.
Published: (2018)

The Perception of Older Generation Y on Luxury and Luxury Brands: An Exploratory Study
by: Suvarnasuddhi, Sarisa
Published: (2007)

How to Motivate Employees of Generation Y in China: From the Perspectives of Financial and Non-financial Rewards
by: Sun, Rui
Published: (2017)

DEF6, a novel substrate for the tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies
by: Hey, Fiona, et al.

Impact of milk protein type on the viability and storage stability of microencapsulated Lactobacillus acidophilus using spray drying
by: Soukoulis, Christos, et al.
Published: (2014)

The bigger picture: the hidden consequences of the sugar reduction strategy for tackling childhood obesity in the UK
by: Anabtawi, Ola
Published: (2020)

Understanding the water use efficiency of sugar beet
by: Barratt, Georgina Elizabeth
Published: (2021)

Molecular mobility and interactions in biopolymer-sugar-water systems
by: Farhat, Imad Akil
Published: (1996)

Investigating the physiological effects of fungicides on sugar beet growth and yields
by: Buckley, Annabelle Kate
Published: (2025)

Linking physicochemical properties and sensory data in fibre-enhanced chocolate-based systems
by: Mouraka, Panagiota
Published: (2025)

Effects of light sources and drying methods on plant growth and steviol glycosides content of stevia (Stevia rebaudiana Bertoni)
by: Rashid, Mohd Aziz
Published: (2017)