Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging
The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional gr...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Royal Society of Chemistry
2018
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| Online Access: | https://eprints.nottingham.ac.uk/48975/ |
| _version_ | 1848797892866736128 |
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| author | Zamberlan, F. Turyanska, L. Patanè, A. Liu, Z. Williams, H.E.L. Fay, M.W. Clarke, P.A. Imamura, Y. Jin, T. Bradshaw, T.D. Thomas, N.R. Grabowska, A.M. |
| author_facet | Zamberlan, F. Turyanska, L. Patanè, A. Liu, Z. Williams, H.E.L. Fay, M.W. Clarke, P.A. Imamura, Y. Jin, T. Bradshaw, T.D. Thomas, N.R. Grabowska, A.M. |
| author_sort | Zamberlan, F. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH 2 , –COOH, OMe and –N3 and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo biodistribution is demonstrated at wavelengths 4 1000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications. |
| first_indexed | 2025-11-14T20:11:06Z |
| format | Article |
| id | nottingham-48975 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:11:06Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-489752020-05-04T19:26:42Z https://eprints.nottingham.ac.uk/48975/ Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging Zamberlan, F. Turyanska, L. Patanè, A. Liu, Z. Williams, H.E.L. Fay, M.W. Clarke, P.A. Imamura, Y. Jin, T. Bradshaw, T.D. Thomas, N.R. Grabowska, A.M. The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH 2 , –COOH, OMe and –N3 and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo biodistribution is demonstrated at wavelengths 4 1000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications. Royal Society of Chemistry 2018-01-12 Article PeerReviewed Zamberlan, F., Turyanska, L., Patanè, A., Liu, Z., Williams, H.E.L., Fay, M.W., Clarke, P.A., Imamura, Y., Jin, T., Bradshaw, T.D., Thomas, N.R. and Grabowska, A.M. (2018) Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6 . pp. 550-555. ISSN 2050-7518 http://pubs.rsc.org/en/content/articlehtml/2018/tb/c7tb02912h doi:10.1039/c7tb02912h doi:10.1039/c7tb02912h |
| spellingShingle | Zamberlan, F. Turyanska, L. Patanè, A. Liu, Z. Williams, H.E.L. Fay, M.W. Clarke, P.A. Imamura, Y. Jin, T. Bradshaw, T.D. Thomas, N.R. Grabowska, A.M. Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging |
| title | Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging |
| title_full | Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging |
| title_fullStr | Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging |
| title_full_unstemmed | Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging |
| title_short | Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging |
| title_sort | stable dhla–peg capped pbs quantum dots: from synthesis to near-infrared biomedical imaging |
| url | https://eprints.nottingham.ac.uk/48975/ https://eprints.nottingham.ac.uk/48975/ https://eprints.nottingham.ac.uk/48975/ |