Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design

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Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design

An alcohol dehydrogenase from the halophilic archaeon Haloferax volcanii (HvADH2) has been engineered by rational design to broaden its substrate scope towards the conversion of a range of aromatic substrates, including flurbiprofenol, that is an intermediate of the non-steroidal anti-inflammatory d...

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Bibliographic Details
Main Authors:	Cassidy, Jennifer, Bruen, Larah, Rosini, Elena, Molla, Gianluca, Pollegioni, Loredano, Paradisi, Francesca
Format:	Article
Published:	Public Library of Science 2017
Online Access:	https://eprints.nottingham.ac.uk/48974/

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