An augmented delivery of the anticancer agent, curcumin, to the colon
This work describes the formulation aspects of an orally viable curcumin-containing mucoadhesive nanoparticulate system for management of colon cancer. Curcumin is documented to possess anticancer properties whilst modified citrus pectin yields a galactose functionality capable of inhibiting the gro...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | https://eprints.nottingham.ac.uk/48907/ |
| _version_ | 1848797875954253824 |
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| author | Sabra, Rayan Billa, Nashiru Roberts, Clive J. |
| author_facet | Sabra, Rayan Billa, Nashiru Roberts, Clive J. |
| author_sort | Sabra, Rayan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | This work describes the formulation aspects of an orally viable curcumin-containing mucoadhesive nanoparticulate system for management of colon cancer. Curcumin is documented to possess anticancer properties whilst modified citrus pectin yields a galactose functionality capable of inhibiting the growth and proliferation of colon cancer cells due to antagonism to galectin-3 (Gal-3). A successfully formulated curcumin containing chitosan-modified citrus pectinate nanoparticles (MCPCNPs) registered a z-average of 178 nm (± 0.896) and a positive surface charge of + 35.7 mV (± 1.41). The MCPCNPs presented high mucoadhesion propensity in the colonic region/ media and minimal at pH 1.2 (stomach). There was approximately 18 % curcumin release at pH 1.2 over 2 h and up to 68% release in the 33% (w/v) caecal medium over 24 h. The data obtained strongly suggests that the formulated MCPCNPs have the potential to be applied as an orally deliverable colon cancer formulation alternative in the treatment of colon cancer. |
| first_indexed | 2025-11-14T20:10:50Z |
| format | Article |
| id | nottingham-48907 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:10:50Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-489072020-05-04T19:30:29Z https://eprints.nottingham.ac.uk/48907/ An augmented delivery of the anticancer agent, curcumin, to the colon Sabra, Rayan Billa, Nashiru Roberts, Clive J. This work describes the formulation aspects of an orally viable curcumin-containing mucoadhesive nanoparticulate system for management of colon cancer. Curcumin is documented to possess anticancer properties whilst modified citrus pectin yields a galactose functionality capable of inhibiting the growth and proliferation of colon cancer cells due to antagonism to galectin-3 (Gal-3). A successfully formulated curcumin containing chitosan-modified citrus pectinate nanoparticles (MCPCNPs) registered a z-average of 178 nm (± 0.896) and a positive surface charge of + 35.7 mV (± 1.41). The MCPCNPs presented high mucoadhesion propensity in the colonic region/ media and minimal at pH 1.2 (stomach). There was approximately 18 % curcumin release at pH 1.2 over 2 h and up to 68% release in the 33% (w/v) caecal medium over 24 h. The data obtained strongly suggests that the formulated MCPCNPs have the potential to be applied as an orally deliverable colon cancer formulation alternative in the treatment of colon cancer. Elsevier 2018-02-01 Article PeerReviewed Sabra, Rayan, Billa, Nashiru and Roberts, Clive J. (2018) An augmented delivery of the anticancer agent, curcumin, to the colon. Reactive and Functional Polymers, 123 . pp. 54-60. ISSN 1381-5148 modified citrus pectin curcumin nano-particulate system colon cancer http://www.sciencedirect.com/science/article/pii/S1381514817302766 doi:10.1016/j.reactfunctpolym.2017.12.012 doi:10.1016/j.reactfunctpolym.2017.12.012 |
| spellingShingle | modified citrus pectin curcumin nano-particulate system colon cancer Sabra, Rayan Billa, Nashiru Roberts, Clive J. An augmented delivery of the anticancer agent, curcumin, to the colon |
| title | An augmented delivery of the anticancer agent, curcumin, to the colon |
| title_full | An augmented delivery of the anticancer agent, curcumin, to the colon |
| title_fullStr | An augmented delivery of the anticancer agent, curcumin, to the colon |
| title_full_unstemmed | An augmented delivery of the anticancer agent, curcumin, to the colon |
| title_short | An augmented delivery of the anticancer agent, curcumin, to the colon |
| title_sort | augmented delivery of the anticancer agent, curcumin, to the colon |
| topic | modified citrus pectin curcumin nano-particulate system colon cancer |
| url | https://eprints.nottingham.ac.uk/48907/ https://eprints.nottingham.ac.uk/48907/ https://eprints.nottingham.ac.uk/48907/ |