Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation
Atypical chronic myeloid leukaemia (aCML) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents the only curative option. We describe transplant outcomes in 42 patients reported to the European Society for Blood and Marrow Transplantation (E...
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| Format: | Article |
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Wiley
2017
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| Online Access: | https://eprints.nottingham.ac.uk/48728/ |
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| author | Onida, Francesco De Wreede, Lliesbeth C. van Blezan, Anja Elkema, Diderik-Jan Byrne, Jenny L. Iori, Anna P. Schots, Rick Jungova, Alexandra Schetelig, Johannes Finke, Juergen Veelken, Hendrick Johanssen, Jan-Erik Craddock, Charles Stellies, Matthias Theobald, Matthias Holler, Ernst Schanz, Urs Schaap, Nicolaas Bittenbring, Joerg Olivaria, Eduardo Chalandan, Yves Kroger, Nicolaus |
| author_facet | Onida, Francesco De Wreede, Lliesbeth C. van Blezan, Anja Elkema, Diderik-Jan Byrne, Jenny L. Iori, Anna P. Schots, Rick Jungova, Alexandra Schetelig, Johannes Finke, Juergen Veelken, Hendrick Johanssen, Jan-Erik Craddock, Charles Stellies, Matthias Theobald, Matthias Holler, Ernst Schanz, Urs Schaap, Nicolaas Bittenbring, Joerg Olivaria, Eduardo Chalandan, Yves Kroger, Nicolaus |
| author_sort | Onida, Francesco |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Atypical chronic myeloid leukaemia (aCML) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents the only curative option. We describe transplant outcomes in 42 patients reported to the European Society for Blood and Marrow Transplantation (EBMT) registry who underwent allo-HSCT for aCML between 1997 and 2006. Median age was 46 years. Median time from diagnosis to transplant was 7 months. Disease status was first chronic phase in 69%. Donors were human leucocyte antigen (HLA)-identical siblings in 64% and matched unrelated (MUD) in 36%. A reduced intensity conditioning was employed in 24% of patients. T-cell depletion was applied in 87% and 26% of transplants from MUD and HLA-identical siblings, respectively. According to the EBMT risk-score, 45% of patients were ‘low-risk’, 31% ‘intermediate-risk’ and 24% ‘high-risk’. Following allo-HSCT, 87% of patients achieved complete remission. At 5 years, relapse-free survival was 36% and non-relapse mortality (NRM) was 24%, while relapse occurred in 40%. Patient age and the EBMT score had an impact on overall survival. Relapse-free survival was higher in MUD than in HLA-identical sibling HSCT, with no difference in NRM. In conclusion, this study confirmed that allo-HSCT represents a valid strategy to achieve cure in a reasonable proportion of patients with aCML, with young patients with low EBMT risk score being the best candidates. |
| first_indexed | 2025-11-14T20:10:10Z |
| format | Article |
| id | nottingham-48728 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:10:10Z |
| publishDate | 2017 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-487282020-05-04T18:48:07Z https://eprints.nottingham.ac.uk/48728/ Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation Onida, Francesco De Wreede, Lliesbeth C. van Blezan, Anja Elkema, Diderik-Jan Byrne, Jenny L. Iori, Anna P. Schots, Rick Jungova, Alexandra Schetelig, Johannes Finke, Juergen Veelken, Hendrick Johanssen, Jan-Erik Craddock, Charles Stellies, Matthias Theobald, Matthias Holler, Ernst Schanz, Urs Schaap, Nicolaas Bittenbring, Joerg Olivaria, Eduardo Chalandan, Yves Kroger, Nicolaus Atypical chronic myeloid leukaemia (aCML) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents the only curative option. We describe transplant outcomes in 42 patients reported to the European Society for Blood and Marrow Transplantation (EBMT) registry who underwent allo-HSCT for aCML between 1997 and 2006. Median age was 46 years. Median time from diagnosis to transplant was 7 months. Disease status was first chronic phase in 69%. Donors were human leucocyte antigen (HLA)-identical siblings in 64% and matched unrelated (MUD) in 36%. A reduced intensity conditioning was employed in 24% of patients. T-cell depletion was applied in 87% and 26% of transplants from MUD and HLA-identical siblings, respectively. According to the EBMT risk-score, 45% of patients were ‘low-risk’, 31% ‘intermediate-risk’ and 24% ‘high-risk’. Following allo-HSCT, 87% of patients achieved complete remission. At 5 years, relapse-free survival was 36% and non-relapse mortality (NRM) was 24%, while relapse occurred in 40%. Patient age and the EBMT score had an impact on overall survival. Relapse-free survival was higher in MUD than in HLA-identical sibling HSCT, with no difference in NRM. In conclusion, this study confirmed that allo-HSCT represents a valid strategy to achieve cure in a reasonable proportion of patients with aCML, with young patients with low EBMT risk score being the best candidates. Wiley 2017-06-01 Article PeerReviewed Onida, Francesco, De Wreede, Lliesbeth C., van Blezan, Anja, Elkema, Diderik-Jan, Byrne, Jenny L., Iori, Anna P., Schots, Rick, Jungova, Alexandra, Schetelig, Johannes, Finke, Juergen, Veelken, Hendrick, Johanssen, Jan-Erik, Craddock, Charles, Stellies, Matthias, Theobald, Matthias, Holler, Ernst, Schanz, Urs, Schaap, Nicolaas, Bittenbring, Joerg, Olivaria, Eduardo, Chalandan, Yves and Kroger, Nicolaus (2017) Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation. British Journal of Haematology, 177 (5). pp. 759-765. ISSN 2836-9779 allogeneic transplantation atypical chronic myeloid leukaemia Myelodyslastic/Myeloproliferative Neoplasms (MDS/MPN) Ph-negative CML:BCR-ABL1-negative http://onlinelibrary.wiley.com/doi/10.1111/bjh.14619/abstract doi: 10.1111/bjh.14619 doi: 10.1111/bjh.14619 |
| spellingShingle | allogeneic transplantation atypical chronic myeloid leukaemia Myelodyslastic/Myeloproliferative Neoplasms (MDS/MPN) Ph-negative CML:BCR-ABL1-negative Onida, Francesco De Wreede, Lliesbeth C. van Blezan, Anja Elkema, Diderik-Jan Byrne, Jenny L. Iori, Anna P. Schots, Rick Jungova, Alexandra Schetelig, Johannes Finke, Juergen Veelken, Hendrick Johanssen, Jan-Erik Craddock, Charles Stellies, Matthias Theobald, Matthias Holler, Ernst Schanz, Urs Schaap, Nicolaas Bittenbring, Joerg Olivaria, Eduardo Chalandan, Yves Kroger, Nicolaus Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation |
| title | Allogeneic stem cell transplantation in patients with atypical
chronic myeloid leukaemia: a retrospective study from the
Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation |
| title_full | Allogeneic stem cell transplantation in patients with atypical
chronic myeloid leukaemia: a retrospective study from the
Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation |
| title_fullStr | Allogeneic stem cell transplantation in patients with atypical
chronic myeloid leukaemia: a retrospective study from the
Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation |
| title_full_unstemmed | Allogeneic stem cell transplantation in patients with atypical
chronic myeloid leukaemia: a retrospective study from the
Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation |
| title_short | Allogeneic stem cell transplantation in patients with atypical
chronic myeloid leukaemia: a retrospective study from the
Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation |
| title_sort | allogeneic stem cell transplantation in patients with atypical
chronic myeloid leukaemia: a retrospective study from the
chronic malignancies working party of the european society for blood and marrow transplantation |
| topic | allogeneic transplantation atypical chronic myeloid leukaemia Myelodyslastic/Myeloproliferative Neoplasms (MDS/MPN) Ph-negative CML:BCR-ABL1-negative |
| url | https://eprints.nottingham.ac.uk/48728/ https://eprints.nottingham.ac.uk/48728/ https://eprints.nottingham.ac.uk/48728/ |