Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives
p-Hydroxybenzoic acid derivatives (p-HBADs) are glycoconjugates secreted by all Mycobacterium tuberculosis isolates whose contribution to pathogenicity remains to be determined. The pathogenicity of three transposon mutants of M. tuberculosis deficient in the biosynthesis of some or all forms of p-H...
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| Format: | Article |
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Elsevier
2006
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| Online Access: | https://eprints.nottingham.ac.uk/48704/ |
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| author | Stadthagen, Gustavo Jackson, Mary Charles, Patricia Boudoua, Frédéric Barilonea, Nathalie Huerree, Michel Constant, Patricia Liav, Avraham Bottova, Iveta Nigou, Jérome Brandod, Thérèse Puzo, Germain Daffé, Mamadou Benjamin, Pearline Coade, Stephen Buxton, Roger S. Tascon, Ricardo E. Rae, Aaron Robertson, Brian D. Lowrie, Douglas B. Young, Douglas B. Gicquel, Brigitte Griffin, R. |
| author_facet | Stadthagen, Gustavo Jackson, Mary Charles, Patricia Boudoua, Frédéric Barilonea, Nathalie Huerree, Michel Constant, Patricia Liav, Avraham Bottova, Iveta Nigou, Jérome Brandod, Thérèse Puzo, Germain Daffé, Mamadou Benjamin, Pearline Coade, Stephen Buxton, Roger S. Tascon, Ricardo E. Rae, Aaron Robertson, Brian D. Lowrie, Douglas B. Young, Douglas B. Gicquel, Brigitte Griffin, R. |
| author_sort | Stadthagen, Gustavo |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | p-Hydroxybenzoic acid derivatives (p-HBADs) are glycoconjugates secreted by all Mycobacterium tuberculosis isolates whose contribution to pathogenicity remains to be determined. The pathogenicity of three transposon mutants of M. tuberculosis deficient in the biosynthesis of some or all forms of p-HBADs was studied. Whilst the mutants grew similarly to the wild-type strain in macrophages and C57BL/6 mice, two of the mutants induced a more severe and diffuse inflammation in the lungs. The lack of production of some or all forms of p-HBADs in these two mutants also correlated with an increased secretion of the pro-inflammatory cytokines tumour-necrosis factor α, interleukin 6 and interleukin 12 in vivo. We propose that the loss of production of p-HBADs by tubercle bacilli results in their diminished ability to suppress the proinflammatory response to infection and that this ultimately provokes extensive pulmonary lesions in the C57BL/6 model of tuberculosis infection. |
| first_indexed | 2025-11-14T20:10:04Z |
| format | Article |
| id | nottingham-48704 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:10:04Z |
| publishDate | 2006 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-487042020-05-04T16:26:26Z https://eprints.nottingham.ac.uk/48704/ Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives Stadthagen, Gustavo Jackson, Mary Charles, Patricia Boudoua, Frédéric Barilonea, Nathalie Huerree, Michel Constant, Patricia Liav, Avraham Bottova, Iveta Nigou, Jérome Brandod, Thérèse Puzo, Germain Daffé, Mamadou Benjamin, Pearline Coade, Stephen Buxton, Roger S. Tascon, Ricardo E. Rae, Aaron Robertson, Brian D. Lowrie, Douglas B. Young, Douglas B. Gicquel, Brigitte Griffin, R. p-Hydroxybenzoic acid derivatives (p-HBADs) are glycoconjugates secreted by all Mycobacterium tuberculosis isolates whose contribution to pathogenicity remains to be determined. The pathogenicity of three transposon mutants of M. tuberculosis deficient in the biosynthesis of some or all forms of p-HBADs was studied. Whilst the mutants grew similarly to the wild-type strain in macrophages and C57BL/6 mice, two of the mutants induced a more severe and diffuse inflammation in the lungs. The lack of production of some or all forms of p-HBADs in these two mutants also correlated with an increased secretion of the pro-inflammatory cytokines tumour-necrosis factor α, interleukin 6 and interleukin 12 in vivo. We propose that the loss of production of p-HBADs by tubercle bacilli results in their diminished ability to suppress the proinflammatory response to infection and that this ultimately provokes extensive pulmonary lesions in the C57BL/6 model of tuberculosis infection. Elsevier 2006-05-30 Article PeerReviewed Stadthagen, Gustavo, Jackson, Mary, Charles, Patricia, Boudoua, Frédéric, Barilonea, Nathalie, Huerree, Michel, Constant, Patricia, Liav, Avraham, Bottova, Iveta, Nigou, Jérome, Brandod, Thérèse, Puzo, Germain, Daffé, Mamadou, Benjamin, Pearline, Coade, Stephen, Buxton, Roger S., Tascon, Ricardo E., Rae, Aaron, Robertson, Brian D., Lowrie, Douglas B., Young, Douglas B., Gicquel, Brigitte and Griffin, R. (2006) Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives. Microbes and Infection, 8 (8). pp. 2245-2253. ISSN 1769-714X Mycobacterium; Tuberculosis; Phenolic glycolipids; p-Hydroxybenzoic acid derivatives http://www.sciencedirect.com/science/article/pii/S1286457906001705?via%3Dihub# doi:10.1016/j.micinf.2006.04.008 doi:10.1016/j.micinf.2006.04.008 |
| spellingShingle | Mycobacterium; Tuberculosis; Phenolic glycolipids; p-Hydroxybenzoic acid derivatives Stadthagen, Gustavo Jackson, Mary Charles, Patricia Boudoua, Frédéric Barilonea, Nathalie Huerree, Michel Constant, Patricia Liav, Avraham Bottova, Iveta Nigou, Jérome Brandod, Thérèse Puzo, Germain Daffé, Mamadou Benjamin, Pearline Coade, Stephen Buxton, Roger S. Tascon, Ricardo E. Rae, Aaron Robertson, Brian D. Lowrie, Douglas B. Young, Douglas B. Gicquel, Brigitte Griffin, R. Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives |
| title | Comparative investigation of the pathogenicity of three
Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives |
| title_full | Comparative investigation of the pathogenicity of three
Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives |
| title_fullStr | Comparative investigation of the pathogenicity of three
Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives |
| title_full_unstemmed | Comparative investigation of the pathogenicity of three
Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives |
| title_short | Comparative investigation of the pathogenicity of three
Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives |
| title_sort | comparative investigation of the pathogenicity of three
mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives |
| topic | Mycobacterium; Tuberculosis; Phenolic glycolipids; p-Hydroxybenzoic acid derivatives |
| url | https://eprints.nottingham.ac.uk/48704/ https://eprints.nottingham.ac.uk/48704/ https://eprints.nottingham.ac.uk/48704/ |