Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data
Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee pain (KP) in a community population. Methods: A...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
BioMed Central
2017
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/48703/ |
| _version_ | 1848797827898015744 |
|---|---|
| author | Sarmanova, Aliya Hall, Michelle C. Fernandes, Gwen Sascha Bhattacharya, Archan Valdes, Ana M. Walsh, David A. Doherty, Michael Zhang, Weiya |
| author_facet | Sarmanova, Aliya Hall, Michelle C. Fernandes, Gwen Sascha Bhattacharya, Archan Valdes, Ana M. Walsh, David A. Doherty, Michael Zhang, Weiya |
| author_sort | Sarmanova, Aliya |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee pain (KP) in a community population.
Methods: A case-control study was conducted to compare people with early KP (n=298), established KP (n=100) or no KP (n=94) at baseline. Multinomial logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) between groups adjusted for radiographic osteoarthritis (ROA) severity and other confounding factors. After one year 255 participants with early and established KP completed the followup questionnaire for changes in KP. Logistic regression with adjustment was used to determine predictors of KP worsening.
Results: At baseline, effusion was associated with early (OR 2.64, 95%CI 1.57 to 4.45) and established KP (OR 5.07, 95%CI 2.74 to 9.38). Synovial hypertrophy was also associated with early (OR 5.43, 95%CI 2.12 to 13.92) and established KP (OR 13.27, 95%CI 4.97 to 35.43). The association with effusion diminished when adjusted for ROA. Power Doppler signal was uncommon (early KP 3%, established KP 2%, controls 0%). Baseline effusion predicted worsening of knee pain at one year (OR 1.95, 95% CI 1.05 to 3.64). However, after adjusting for ROA, the prediction was insignificant (aORs 0.95, 95%CI 0.44 to 2.02).
Conclusion: US effusion and synovial hypertrophy are associated with KP, but only effusion predicts KP worsening. However, the association/prediction are not independent from ROA. Power Doppler signal is uncommon in people with KP. Further study is needed to understand whether synovitis is directly involved in different types of KP. |
| first_indexed | 2025-11-14T20:10:04Z |
| format | Article |
| id | nottingham-48703 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:10:04Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-487032020-05-04T19:23:38Z https://eprints.nottingham.ac.uk/48703/ Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data Sarmanova, Aliya Hall, Michelle C. Fernandes, Gwen Sascha Bhattacharya, Archan Valdes, Ana M. Walsh, David A. Doherty, Michael Zhang, Weiya Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee pain (KP) in a community population. Methods: A case-control study was conducted to compare people with early KP (n=298), established KP (n=100) or no KP (n=94) at baseline. Multinomial logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) between groups adjusted for radiographic osteoarthritis (ROA) severity and other confounding factors. After one year 255 participants with early and established KP completed the followup questionnaire for changes in KP. Logistic regression with adjustment was used to determine predictors of KP worsening. Results: At baseline, effusion was associated with early (OR 2.64, 95%CI 1.57 to 4.45) and established KP (OR 5.07, 95%CI 2.74 to 9.38). Synovial hypertrophy was also associated with early (OR 5.43, 95%CI 2.12 to 13.92) and established KP (OR 13.27, 95%CI 4.97 to 35.43). The association with effusion diminished when adjusted for ROA. Power Doppler signal was uncommon (early KP 3%, established KP 2%, controls 0%). Baseline effusion predicted worsening of knee pain at one year (OR 1.95, 95% CI 1.05 to 3.64). However, after adjusting for ROA, the prediction was insignificant (aORs 0.95, 95%CI 0.44 to 2.02). Conclusion: US effusion and synovial hypertrophy are associated with KP, but only effusion predicts KP worsening. However, the association/prediction are not independent from ROA. Power Doppler signal is uncommon in people with KP. Further study is needed to understand whether synovitis is directly involved in different types of KP. BioMed Central 2017-12-19 Article PeerReviewed Sarmanova, Aliya, Hall, Michelle C., Fernandes, Gwen Sascha, Bhattacharya, Archan, Valdes, Ana M., Walsh, David A., Doherty, Michael and Zhang, Weiya (2017) Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. Arthritis Research & Therapy, 19 (281). pp. 1-9. ISSN 1478-6362 knee pain synovial changes synovitis ultrasound osteoarthritis cohort study https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1486-7 doi:10.1186/s13075-017-1486-7 doi:10.1186/s13075-017-1486-7 |
| spellingShingle | knee pain synovial changes synovitis ultrasound osteoarthritis cohort study Sarmanova, Aliya Hall, Michelle C. Fernandes, Gwen Sascha Bhattacharya, Archan Valdes, Ana M. Walsh, David A. Doherty, Michael Zhang, Weiya Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data |
| title | Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data |
| title_full | Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data |
| title_fullStr | Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data |
| title_full_unstemmed | Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data |
| title_short | Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data |
| title_sort | association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data |
| topic | knee pain synovial changes synovitis ultrasound osteoarthritis cohort study |
| url | https://eprints.nottingham.ac.uk/48703/ https://eprints.nottingham.ac.uk/48703/ https://eprints.nottingham.ac.uk/48703/ |