Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages
Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characte...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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ASM Press
2007
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| Online Access: | https://eprints.nottingham.ac.uk/48696/ |
| _version_ | 1848797825658257408 |
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| author | Rosas-Magallanes, Vania Stadthagen-Gomez, Gustavo Rauzier, Jean Barreiro, Luis B. Tailleux, Ludovic Boudou, Frédéric Griffin, Ruth Nigou, Jérome Jackson, Mary Gicquel, Brigittte Neyrolles, Olivier |
| author_facet | Rosas-Magallanes, Vania Stadthagen-Gomez, Gustavo Rauzier, Jean Barreiro, Luis B. Tailleux, Ludovic Boudou, Frédéric Griffin, Ruth Nigou, Jérome Jackson, Mary Gicquel, Brigittte Neyrolles, Olivier |
| author_sort | Rosas-Magallanes, Vania |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells. |
| first_indexed | 2025-11-14T20:10:02Z |
| format | Article |
| id | nottingham-48696 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:10:02Z |
| publishDate | 2007 |
| publisher | ASM Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-486962020-05-04T16:26:42Z https://eprints.nottingham.ac.uk/48696/ Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages Rosas-Magallanes, Vania Stadthagen-Gomez, Gustavo Rauzier, Jean Barreiro, Luis B. Tailleux, Ludovic Boudou, Frédéric Griffin, Ruth Nigou, Jérome Jackson, Mary Gicquel, Brigittte Neyrolles, Olivier Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells. ASM Press 2007-01-01 Article PeerReviewed Rosas-Magallanes, Vania, Stadthagen-Gomez, Gustavo, Rauzier, Jean, Barreiro, Luis B., Tailleux, Ludovic, Boudou, Frédéric, Griffin, Ruth, Nigou, Jérome, Jackson, Mary, Gicquel, Brigittte and Neyrolles, Olivier (2007) Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infection and Immunity, 75 (1). 504 -507. ISSN 1098-5522 http://iai.asm.org/content/75/1/504 doi:10.1128/IAI.00058-06. doi:10.1128/IAI.00058-06. |
| spellingShingle | Rosas-Magallanes, Vania Stadthagen-Gomez, Gustavo Rauzier, Jean Barreiro, Luis B. Tailleux, Ludovic Boudou, Frédéric Griffin, Ruth Nigou, Jérome Jackson, Mary Gicquel, Brigittte Neyrolles, Olivier Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
| title | Signature-tagged transposon mutagenesis identifies novel
mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
| title_full | Signature-tagged transposon mutagenesis identifies novel
mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
| title_fullStr | Signature-tagged transposon mutagenesis identifies novel
mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
| title_full_unstemmed | Signature-tagged transposon mutagenesis identifies novel
mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
| title_short | Signature-tagged transposon mutagenesis identifies novel
mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
| title_sort | signature-tagged transposon mutagenesis identifies novel
mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
| url | https://eprints.nottingham.ac.uk/48696/ https://eprints.nottingham.ac.uk/48696/ https://eprints.nottingham.ac.uk/48696/ |