Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells

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Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells

Airway epithelial cells in cystic fibrosis (CF) overexpress Interleukin 8 (CXCL8) through poorly defined mechanisms. CXCL8 transcription is dependent on coordinated binding of CCAAT/enhancer binding protein (C/EBP)β, nuclear factor (NF)-κB, and activator protein (AP)-1 to the promoter. Here we show...

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Bibliographic Details
Main Authors:	Poghosyan, Anna, Patel, Jamie K., Clifford, Rachel L., Knox, Alan J.
Format:	Article
Published:	Elsevier 2016
Subjects:	CF; Epigenetics; CXCL8; BRD4
Online Access:	https://eprints.nottingham.ac.uk/48678/

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