Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS

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Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS

ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method extends to three other cell lines relevant to drug discovery: human embryonic kidney (HEK293), cervical cancer (HeLa), and liver...

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Bibliographic Details
Main Authors:	Newman, Carla F., Havelund, Rasmus, Passarelli, Melissa K., Marshall, Peter S., Francis, Ian, West, Andy, Alexander, Morgan R., Gilmore, Ian S., Dollery, Colin T.
Format:	Article
Published:	American Chemical Society 2017
Online Access:	https://eprints.nottingham.ac.uk/48607/

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