Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS

ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method extends to three other cell lines relevant to drug discovery: human embryonic kidney (HEK293), cervical cancer (HeLa), and liver...

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Main Authors: Newman, Carla F., Havelund, Rasmus, Passarelli, Melissa K., Marshall, Peter S., Francis, Ian, West, Andy, Alexander, Morgan R., Gilmore, Ian S., Dollery, Colin T.
Format: Article
Published: American Chemical Society 2017
Online Access:https://eprints.nottingham.ac.uk/48607/
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author Newman, Carla F.
Havelund, Rasmus
Passarelli, Melissa K.
Marshall, Peter S.
Francis, Ian
West, Andy
Alexander, Morgan R.
Gilmore, Ian S.
Dollery, Colin T.
author_facet Newman, Carla F.
Havelund, Rasmus
Passarelli, Melissa K.
Marshall, Peter S.
Francis, Ian
West, Andy
Alexander, Morgan R.
Gilmore, Ian S.
Dollery, Colin T.
author_sort Newman, Carla F.
building Nottingham Research Data Repository
collection Online Access
description ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method extends to three other cell lines relevant to drug discovery: human embryonic kidney (HEK293), cervical cancer (HeLa), and liver cancer (HepG2). There is significant interest in the variation of drug uptake at the single cell level, and we use ToF-SIMS to show that there is great diversity between individual cells and when comparing each of the cell types. These single cell measurements are compared to quantitative measurements of cell-associated amiodarone for the population using LC/MS/MS and cell counting with flow cytometry. NR8383 and HepG2 cells uptake the greatest amount of amiodarone with an average of 2.38 and 2.60 pg per cell, respectively, and HeLa and Hek 293 have a significantly lower amount of amiodarone at 0.43 and 0.36 pg per cell, respectively. The amount of cell-associated drug for the ensemble population measurement (LC/MS/MS) is compared with the ToF-SIMS single cell data: a similar amount of drug was detected per cell for the NR8383, and HepG2 cells at a greater level than that for the HEK293 cells. However, the two techniques did not agree for the HeLa cells, and we postulate potential reasons for this.
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spelling nottingham-486072020-05-04T19:16:57Z https://eprints.nottingham.ac.uk/48607/ Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS Newman, Carla F. Havelund, Rasmus Passarelli, Melissa K. Marshall, Peter S. Francis, Ian West, Andy Alexander, Morgan R. Gilmore, Ian S. Dollery, Colin T. ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method extends to three other cell lines relevant to drug discovery: human embryonic kidney (HEK293), cervical cancer (HeLa), and liver cancer (HepG2). There is significant interest in the variation of drug uptake at the single cell level, and we use ToF-SIMS to show that there is great diversity between individual cells and when comparing each of the cell types. These single cell measurements are compared to quantitative measurements of cell-associated amiodarone for the population using LC/MS/MS and cell counting with flow cytometry. NR8383 and HepG2 cells uptake the greatest amount of amiodarone with an average of 2.38 and 2.60 pg per cell, respectively, and HeLa and Hek 293 have a significantly lower amount of amiodarone at 0.43 and 0.36 pg per cell, respectively. The amount of cell-associated drug for the ensemble population measurement (LC/MS/MS) is compared with the ToF-SIMS single cell data: a similar amount of drug was detected per cell for the NR8383, and HepG2 cells at a greater level than that for the HEK293 cells. However, the two techniques did not agree for the HeLa cells, and we postulate potential reasons for this. American Chemical Society 2017-11-10 Article PeerReviewed Newman, Carla F., Havelund, Rasmus, Passarelli, Melissa K., Marshall, Peter S., Francis, Ian, West, Andy, Alexander, Morgan R., Gilmore, Ian S. and Dollery, Colin T. (2017) Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS. Analytical Chemistry, 89 (22). pp. 11944-11953. ISSN 1520-6882 https://doi.org/10.1021/acs.analchem.7b01436 doi:10.1021/acs.analchem.7b01436 doi:10.1021/acs.analchem.7b01436
spellingShingle Newman, Carla F.
Havelund, Rasmus
Passarelli, Melissa K.
Marshall, Peter S.
Francis, Ian
West, Andy
Alexander, Morgan R.
Gilmore, Ian S.
Dollery, Colin T.
Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS
title Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS
title_full Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS
title_fullStr Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS
title_full_unstemmed Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS
title_short Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS
title_sort intracellular drug uptake: a comparison of single cell measurements using tof-sims imaging and quantification from cell populations with lc/ms/ms
url https://eprints.nottingham.ac.uk/48607/
https://eprints.nottingham.ac.uk/48607/
https://eprints.nottingham.ac.uk/48607/