Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation
A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after lo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Wiley
2015
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| Online Access: | https://eprints.nottingham.ac.uk/48601/ |
| _version_ | 1848797803863605248 |
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| author | Celiz, Adam D. Smith, James G.W. Patel, Asha K. Hook, Andrew L. Rajamohan, Divya George, Vinoj T. Flatt, Luke Patel, Minal J. Epa, Vidana C. Singh, Taranjit Langer, Robert Anderson, Daniel G. Allen, Nicholas D. Hay, David C. Winkler, David A. Barrett, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. |
| author_facet | Celiz, Adam D. Smith, James G.W. Patel, Asha K. Hook, Andrew L. Rajamohan, Divya George, Vinoj T. Flatt, Luke Patel, Minal J. Epa, Vidana C. Singh, Taranjit Langer, Robert Anderson, Daniel G. Allen, Nicholas D. Hay, David C. Winkler, David A. Barrett, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. |
| author_sort | Celiz, Adam D. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized. |
| first_indexed | 2025-11-14T20:09:41Z |
| format | Article |
| id | nottingham-48601 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:09:41Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-486012020-05-04T17:12:59Z https://eprints.nottingham.ac.uk/48601/ Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation Celiz, Adam D. Smith, James G.W. Patel, Asha K. Hook, Andrew L. Rajamohan, Divya George, Vinoj T. Flatt, Luke Patel, Minal J. Epa, Vidana C. Singh, Taranjit Langer, Robert Anderson, Daniel G. Allen, Nicholas D. Hay, David C. Winkler, David A. Barrett, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized. Wiley 2015-07-15 Article PeerReviewed Celiz, Adam D., Smith, James G.W., Patel, Asha K., Hook, Andrew L., Rajamohan, Divya, George, Vinoj T., Flatt, Luke, Patel, Minal J., Epa, Vidana C., Singh, Taranjit, Langer, Robert, Anderson, Daniel G., Allen, Nicholas D., Hay, David C., Winkler, David A., Barrett, David A., Davies, Martyn C., Young, Lorraine E., Denning, Chris and Alexander, Morgan R. (2015) Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials, 27 (27). pp. 4006-4012. ISSN 0935-9648 high throughput; human pluripotent stem cells; materials discovery; polymer microarrays; stem cell differentiation http://onlinelibrary.wiley.com/doi/10.1002/adma.201501351/full doi:10.1002/adma.201501351 doi:10.1002/adma.201501351 |
| spellingShingle | high throughput; human pluripotent stem cells; materials discovery; polymer microarrays; stem cell differentiation Celiz, Adam D. Smith, James G.W. Patel, Asha K. Hook, Andrew L. Rajamohan, Divya George, Vinoj T. Flatt, Luke Patel, Minal J. Epa, Vidana C. Singh, Taranjit Langer, Robert Anderson, Daniel G. Allen, Nicholas D. Hay, David C. Winkler, David A. Barrett, David A. Davies, Martyn C. Young, Lorraine E. Denning, Chris Alexander, Morgan R. Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation |
| title | Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation |
| title_full | Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation |
| title_fullStr | Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation |
| title_full_unstemmed | Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation |
| title_short | Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation |
| title_sort | discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation |
| topic | high throughput; human pluripotent stem cells; materials discovery; polymer microarrays; stem cell differentiation |
| url | https://eprints.nottingham.ac.uk/48601/ https://eprints.nottingham.ac.uk/48601/ https://eprints.nottingham.ac.uk/48601/ |