Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity
A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria is explored, comparing cyclic, aromatic, and linear...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Wiley
2015
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/48600/ |
| _version_ | 1848797803586781184 |
|---|---|
| author | Sanni, Olutoba Chang, Chien-Yi Anderson, Daniel G. Langer, Robert Davies, Martyn C. Williams, Philip M. Williams, Paul Alexander, Morgan R. Hook, Andrew L. |
| author_facet | Sanni, Olutoba Chang, Chien-Yi Anderson, Daniel G. Langer, Robert Davies, Martyn C. Williams, Philip M. Williams, Paul Alexander, Morgan R. Hook, Andrew L. |
| author_sort | Sanni, Olutoba |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria is explored, comparing cyclic, aromatic, and linear chemical groups. A correlation is shown between bacterial attachment and a parameter derived from the partition coefficient and the number of rotatable bonds of the materials' pendant groups. This correlation is applicable to 86% of the hydrocarbon pendant moieties surveyed, quantitatively supporting the previous qualitative observation that bacteria are repelled from poly (meth)acrylates containing a hydrophilic ester group when the pendant group is both rigid and hydrophobic. This insight will help inform and predict the further development of polymers resistant to bacterial attachment. |
| first_indexed | 2025-11-14T20:09:41Z |
| format | Article |
| id | nottingham-48600 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:09:41Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-486002020-05-04T17:07:10Z https://eprints.nottingham.ac.uk/48600/ Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity Sanni, Olutoba Chang, Chien-Yi Anderson, Daniel G. Langer, Robert Davies, Martyn C. Williams, Philip M. Williams, Paul Alexander, Morgan R. Hook, Andrew L. A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria is explored, comparing cyclic, aromatic, and linear chemical groups. A correlation is shown between bacterial attachment and a parameter derived from the partition coefficient and the number of rotatable bonds of the materials' pendant groups. This correlation is applicable to 86% of the hydrocarbon pendant moieties surveyed, quantitatively supporting the previous qualitative observation that bacteria are repelled from poly (meth)acrylates containing a hydrophilic ester group when the pendant group is both rigid and hydrophobic. This insight will help inform and predict the further development of polymers resistant to bacterial attachment. Wiley 2015-04-02 Article PeerReviewed Sanni, Olutoba, Chang, Chien-Yi, Anderson, Daniel G., Langer, Robert, Davies, Martyn C., Williams, Philip M., Williams, Paul, Alexander, Morgan R. and Hook, Andrew L. (2015) Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity. Advanced Healthcare Materials, 4 (5). pp. 695-701. ISSN 2192-2640 low-fouling; molecular descriptors; polymer microarrays; Pseudomonas aeruginosa ; ion mass spectrometry http://onlinelibrary.wiley.com/doi/10.1002/adhm.201400648/abstract doi:10.1002/adhm.201400648 doi:10.1002/adhm.201400648 |
| spellingShingle | low-fouling; molecular descriptors; polymer microarrays; Pseudomonas aeruginosa ; ion mass spectrometry Sanni, Olutoba Chang, Chien-Yi Anderson, Daniel G. Langer, Robert Davies, Martyn C. Williams, Philip M. Williams, Paul Alexander, Morgan R. Hook, Andrew L. Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity |
| title | Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity |
| title_full | Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity |
| title_fullStr | Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity |
| title_full_unstemmed | Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity |
| title_short | Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity |
| title_sort | bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity |
| topic | low-fouling; molecular descriptors; polymer microarrays; Pseudomonas aeruginosa ; ion mass spectrometry |
| url | https://eprints.nottingham.ac.uk/48600/ https://eprints.nottingham.ac.uk/48600/ https://eprints.nottingham.ac.uk/48600/ |