Patterns of grey matter loss associated with motor subscores in early Parkinson's disease
Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associa...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/48360/ |
| _version_ | 1848797747257278464 |
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| author | Li, Xingfeng Xing, Yue Martin-Bastida, Antonio Piccini, Paola Auer, Dorothee P. |
| author_facet | Li, Xingfeng Xing, Yue Martin-Bastida, Antonio Piccini, Paola Auer, Dorothee P. |
| author_sort | Li, Xingfeng |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associated with different anatomical patterns of neurodegeneration as reflected by brain grey matter (GM) alteration. This study aimed to investigate associations between motor subscores and brain GM at voxel level. High resolution structural MRI T1 scans from the Parkinson's Progression Markers Initiative (PPMI) repository were employed to estimate brain GM intensity of PD subjects. Correlations between GM intensity and total MDS-UPDRS III and its four subscores were computed. The total MDS-UPDRS III score was significantly negatively correlated bilaterally with putamen and caudate GM density. Lower anterior striatal GM intensity was significantly associated with higher rigidity subscores, whereas left-sided anterior striatal and precentral cortical GM reduction were correlated with severity of axial symptoms. No significant morphometric associations were demonstrated for tremor subscores. In conclusion, we provide evidence for neuroanatomical patterns underpinning motor symptoms in early PD. |
| first_indexed | 2025-11-14T20:08:47Z |
| format | Article |
| id | nottingham-48360 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:08:47Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-483602020-05-04T19:16:55Z https://eprints.nottingham.ac.uk/48360/ Patterns of grey matter loss associated with motor subscores in early Parkinson's disease Li, Xingfeng Xing, Yue Martin-Bastida, Antonio Piccini, Paola Auer, Dorothee P. Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associated with different anatomical patterns of neurodegeneration as reflected by brain grey matter (GM) alteration. This study aimed to investigate associations between motor subscores and brain GM at voxel level. High resolution structural MRI T1 scans from the Parkinson's Progression Markers Initiative (PPMI) repository were employed to estimate brain GM intensity of PD subjects. Correlations between GM intensity and total MDS-UPDRS III and its four subscores were computed. The total MDS-UPDRS III score was significantly negatively correlated bilaterally with putamen and caudate GM density. Lower anterior striatal GM intensity was significantly associated with higher rigidity subscores, whereas left-sided anterior striatal and precentral cortical GM reduction were correlated with severity of axial symptoms. No significant morphometric associations were demonstrated for tremor subscores. In conclusion, we provide evidence for neuroanatomical patterns underpinning motor symptoms in early PD. Elsevier 2017-11-10 Article PeerReviewed Li, Xingfeng, Xing, Yue, Martin-Bastida, Antonio, Piccini, Paola and Auer, Dorothee P. (2017) Patterns of grey matter loss associated with motor subscores in early Parkinson's disease. NeuroImage: Clinical, 17 . pp. 498-504. ISSN 2213-1582 Parkinson's disease; MDS-UPDRS III; Motor symptoms; MRI grey matter; PD subtypes https://doi.org/10.1016/j.nicl.2017.11.009 doi:10.1016/j.nicl.2017.11.009 doi:10.1016/j.nicl.2017.11.009 |
| spellingShingle | Parkinson's disease; MDS-UPDRS III; Motor symptoms; MRI grey matter; PD subtypes Li, Xingfeng Xing, Yue Martin-Bastida, Antonio Piccini, Paola Auer, Dorothee P. Patterns of grey matter loss associated with motor subscores in early Parkinson's disease |
| title | Patterns of grey matter loss associated with motor subscores in early Parkinson's disease |
| title_full | Patterns of grey matter loss associated with motor subscores in early Parkinson's disease |
| title_fullStr | Patterns of grey matter loss associated with motor subscores in early Parkinson's disease |
| title_full_unstemmed | Patterns of grey matter loss associated with motor subscores in early Parkinson's disease |
| title_short | Patterns of grey matter loss associated with motor subscores in early Parkinson's disease |
| title_sort | patterns of grey matter loss associated with motor subscores in early parkinson's disease |
| topic | Parkinson's disease; MDS-UPDRS III; Motor symptoms; MRI grey matter; PD subtypes |
| url | https://eprints.nottingham.ac.uk/48360/ https://eprints.nottingham.ac.uk/48360/ https://eprints.nottingham.ac.uk/48360/ |