The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power

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The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power

We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 nm for inorganic species and under 2 μm for biomolecules) with the high mass-resolving power of an Orbitrap (>240,00...

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Bibliographic Details
Main Authors:	Passarelli, Melissa K., Pirkl, Alexander, Moellers, Rudolf, Grinfeld, Dmitry, Kollmer, Felix, Havelund, Rasmus, Newman, Carla F., Marshall, Peter S., Arlinghaus, Henrik, Alexander, Morgan R., West, Andy, Horning, Stevan, Niehuis, Ewald, Makarov, Alexander, Dollery, Colin T., Gilmore, Ian S.
Format:	Article
Published:	Nature Publishing Group 2017
Subjects:	Drug discovery Imaging Mass spectrometry Metabolomics
Online Access:	https://eprints.nottingham.ac.uk/48339/

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